Lessi, M.; Nania, A.; Pittari, M.; Lodone, L.; Cuzzola, A.; Bellina, F. Palladium-Catalyzed Dehydrogenative C-2 Alkenylation of 5-Arylimidazoles and Related Azoles with Styrenes. Catalysts2021, 11, 762.
Lessi, M.; Nania, A.; Pittari, M.; Lodone, L.; Cuzzola, A.; Bellina, F. Palladium-Catalyzed Dehydrogenative C-2 Alkenylation of 5-Arylimidazoles and Related Azoles with Styrenes. Catalysts 2021, 11, 762.
Lessi, M.; Nania, A.; Pittari, M.; Lodone, L.; Cuzzola, A.; Bellina, F. Palladium-Catalyzed Dehydrogenative C-2 Alkenylation of 5-Arylimidazoles and Related Azoles with Styrenes. Catalysts2021, 11, 762.
Lessi, M.; Nania, A.; Pittari, M.; Lodone, L.; Cuzzola, A.; Bellina, F. Palladium-Catalyzed Dehydrogenative C-2 Alkenylation of 5-Arylimidazoles and Related Azoles with Styrenes. Catalysts 2021, 11, 762.
Abstract
The construction of carbon-carbon bonds by direct involvement of two unactivated carbon-hydrogen bonds, without any directing group, ensures an high atom economy of the entire process. Here it is described a simple protocol for the Pd(II)/Cu(II)-promoted intermolecular cross-dehydrogenative coupling (CDC) of 5-arylimidazoles, benzimidazoles, benzoxazole and 4,5-diphenylimidazole at their C-2 position with functionalized styrenes. This specific CDC, known as Fujiwara-Moritani reaction or oxidative Heck coupling, allowed also the C-4 alkenylation of the imidazole nucleus when both 2 and 5 positions are occupied.
Chemistry and Materials Science, Analytical Chemistry
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