Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Pumice as a Novel Nature Heterogeneous Catalyst for Synthesis of 3,4-dihydropyrimidine-2-(1H)-Ones/Thiones via Biginelli Reaction under Solvent-free Conditions

Version 1 : Received: 30 April 2021 / Approved: 20 May 2021 / Online: 20 May 2021 (13:38:53 CEST)

How to cite: Al-Wahaibi, L.H.; Abdelhamid, A.A.; Saber, S.A.; Elkanzi, N.A.; Ali, A.M. Pumice as a Novel Nature Heterogeneous Catalyst for Synthesis of 3,4-dihydropyrimidine-2-(1H)-Ones/Thiones via Biginelli Reaction under Solvent-free Conditions. Preprints 2021, 2021050493 (doi: 10.20944/preprints202105.0493.v1). Al-Wahaibi, L.H.; Abdelhamid, A.A.; Saber, S.A.; Elkanzi, N.A.; Ali, A.M. Pumice as a Novel Nature Heterogeneous Catalyst for Synthesis of 3,4-dihydropyrimidine-2-(1H)-Ones/Thiones via Biginelli Reaction under Solvent-free Conditions. Preprints 2021, 2021050493 (doi: 10.20944/preprints202105.0493.v1).

Abstract

Abstract: An efficient and environmentally Pumice as a new catalyst for designing of 3,4- dihydropyrimidin-2(1H) ones / thiones via one-pot multi component condensation of aromatic aldehydes, urea/ thiourea and ethyl acetoacetate or acetyl acetone in excellent yields (96-99 %). The advantages using of this new catalyst is very cheap, available, non-toxic, stable under thermal conditions, easy work-up, improved yields, the product of reaction is very pure without using chromatographic methods and solvent free conditions.

Subject Areas

One pot reaction; 3,4- Dihydropyrimidin-2(1H) ones / thiones and Pumice

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