Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Chemical Characterization of the Lichen-symbiont Microalga Asterochloris erici and Study of Its Cytostatic Effect on the L929 Murine Fibrosarcoma Cell Line

Version 1 : Received: 18 May 2021 / Approved: 20 May 2021 / Online: 20 May 2021 (09:11:44 CEST)

A peer-reviewed article of this Preprint also exists.

Matesanz, M.C.; Villa-Carvajal, M.; Linares, J.; Morante-Zarcero, S.; Sierra, I.; Barreno, E.; Catalá, M.; Portolés, M.T. Chemical Characterization of the Lichen-Symbiont Microalga Asterochloris erici and Study of Its Cytostatic Effect on the L929 Murine Fibrosarcoma Cell Line. Processes 2021, 9, 1509. Matesanz, M.C.; Villa-Carvajal, M.; Linares, J.; Morante-Zarcero, S.; Sierra, I.; Barreno, E.; Catalá, M.; Portolés, M.T. Chemical Characterization of the Lichen-Symbiont Microalga Asterochloris erici and Study of Its Cytostatic Effect on the L929 Murine Fibrosarcoma Cell Line. Processes 2021, 9, 1509.

Journal reference: Processes 2021, 9, 1509
DOI: 10.3390/pr9091509

Abstract

New resources of food, pharmaceuticals or biotechnological products are needed. The huge biodiversity of aero-terrestrial lichen-symbiont microalgae remains unexplored. Viability of these for human consumption demands the demonstration of the absence of toxic effects. In vitro biocompatibility of crude homogenates of axenic microalga Asterochloris erici, symbiotic in the lichen Cladonia cristatella, was analyzed after treatment of cultured L929 fibroblasts with different doses of microalgal homogenates. The results show that crude homogenates of A. erici do not induce fibroblast cytotoxicity but seem to have some cytostatic effect inducing slight cell cycle alterations and intracellular reactive oxygen species (ROS) increase at the highest dose. Carotenoid analysis demonstrates high content of lutein, a xanthophyll with antioxidant and cytostatic properties in vivo. These findings confirm that Asterochloris erici can be considered suitable for the development of alimentary or pharmaceutical applications. The cytostatic effects should be further investigated for antitumor agents.

Keywords

bioactivity; phytochemistry; cytostatic, cytotoxicity; microalga

Subject

LIFE SCIENCES, Biochemistry

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