Submitted:
13 May 2021
Posted:
14 May 2021
You are already at the latest version
Abstract
In this tutorial review, we compare and contrast the chemical mechanisms of electrophile/oxidant sensing, and the molecular mechanisms of signal propagation. We critically analyze biological systems in which these different pathways are believed to be manifest and what the data really mean. Finally, we discuss applications of this knowledge to disease treatment and drug development.
Keywords:
RES
; ROS
; reactive chemical species
; electrophile signaling
; cysteine
; LDE
; T-REX
; G-REX
; Chemical Biology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
