Version 1
: Received: 13 May 2021 / Approved: 14 May 2021 / Online: 14 May 2021 (13:45:08 CEST)
How to cite:
Long, M.; Huang, K.; Aye, Y. The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling. Preprints2021, 2021050334. https://doi.org/10.20944/preprints202105.0334.v1.
Long, M.; Huang, K.; Aye, Y. The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling. Preprints 2021, 2021050334. https://doi.org/10.20944/preprints202105.0334.v1.
Cite as:
Long, M.; Huang, K.; Aye, Y. The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling. Preprints2021, 2021050334. https://doi.org/10.20944/preprints202105.0334.v1.
Long, M.; Huang, K.; Aye, Y. The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling. Preprints 2021, 2021050334. https://doi.org/10.20944/preprints202105.0334.v1.
Abstract
In this tutorial review, we compare and contrast the chemical mechanisms of electrophile/oxidant sensing, and the molecular mechanisms of signal propagation. We critically analyze biological systems in which these different pathways are believed to be manifest and what the data really mean. Finally, we discuss applications of this knowledge to disease treatment and drug development.
Keywords
RES; ROS; reactive chemical species; electrophile signaling; cysteine; LDE; T-REX; G-REX; Chemical Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
