Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling

Version 1 : Received: 13 May 2021 / Approved: 14 May 2021 / Online: 14 May 2021 (13:45:08 CEST)

How to cite: Long, M.; Huang, K.; Aye, Y. The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling. Preprints 2021, 2021050334 (doi: 10.20944/preprints202105.0334.v1). Long, M.; Huang, K.; Aye, Y. The not so Identical Twins: (dis)similarities between Reactive Electrophile and Oxidant Sensing and Signaling. Preprints 2021, 2021050334 (doi: 10.20944/preprints202105.0334.v1).

Abstract

In this tutorial review, we compare and contrast the chemical mechanisms of electrophile/oxidant sensing, and the molecular mechanisms of signal propagation. We critically analyze biological systems in which these different pathways are believed to be manifest and what the data really mean. Finally, we discuss applications of this knowledge to disease treatment and drug development.

Subject Areas

RES; ROS; reactive chemical species; electrophile signaling; cysteine; LDE; T-REX; G-REX; Chemical Biology

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