Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Laparoscopic vs Open Pancreaticoduodenectomy- An Updated Metaanalysis of Randomized Control Trials

Version 1 : Received: 8 May 2021 / Approved: 13 May 2021 / Online: 13 May 2021 (13:11:34 CEST)

How to cite: Vasavada, B.; Patel, H. Laparoscopic vs Open Pancreaticoduodenectomy- An Updated Metaanalysis of Randomized Control Trials. Preprints 2021, 2021050295 (doi: 10.20944/preprints202105.0295.v1). Vasavada, B.; Patel, H. Laparoscopic vs Open Pancreaticoduodenectomy- An Updated Metaanalysis of Randomized Control Trials. Preprints 2021, 2021050295 (doi: 10.20944/preprints202105.0295.v1).

Abstract

Background: There is ongoing debate regarding the usefulness of laparoscopic pancreaticoduodenectomy. This study aimed to analyze all the randomized control trials published including the most recent one. Material and methods: The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and MOOSE guidelines. Heterogeneity was measured using Q tests and I2. The random-effects models were used to summarise the relative risks, odds ratios, and mean differences as appropriate.Results:4 RCTs were included consisting of 818 patients. 411 patients were in the laparoscopic group and 407 in the open pancreaticoduodenectomy group. Weighted baseline patient characteristics were similar except more patients with pancreatic adenocarcinoma and more males were there in the open pancreaticoduodenectomy group. There was no difference in-hospital stay,90 days complications rate, 90 days mortality, R1 resection, postoperative pancreatic fistula, delayed gastric emptying, post pancreatectomy hemorrhage, bile leak between the two groups. Operative time was more in the laparoscopic group. Blood loss [mean difference -132.12 ml (-172.60,-91.65)] and surgical site infection [Risk ratio 0.41 ( 0.17-1.0)] were significantly lesser in laparoscopic group.Conclusion:There was no benefit in-hospital stay or clinical outcomes after laparoscopic pancreaticoduodenectomy. Blood loss and surgical site infection were lesser in laparoscopic pancreaticoduodenectomy.

Keywords

Pancreaticoduodenectomy: pancreatic cancer; peri ampullary cancer; laparoscopic surgery

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