Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Coupling Between Sequence-Mediated Nucleosome Organization and Genome Evolution

Version 1 : Received: 5 May 2021 / Approved: 10 May 2021 / Online: 10 May 2021 (10:50:00 CEST)

A peer-reviewed article of this Preprint also exists.

Barbier, J.; Vaillant, C.; Volff, J.-N.; Brunet, F.G.; Audit, B. Coupling between Sequence-Mediated Nucleosome Organization and Genome Evolution. Genes 2021, 12, 851. Barbier, J.; Vaillant, C.; Volff, J.-N.; Brunet, F.G.; Audit, B. Coupling between Sequence-Mediated Nucleosome Organization and Genome Evolution. Genes 2021, 12, 851.

Journal reference: Genes 2021, 12, 851
DOI: 10.3390/genes12060851

Abstract

The nucleosome is a major modulator of DNA accessibility to other cellular factors. Nucleosome positioning has a critical importance in regulating cell processes such as transcription, replication, recombination or DNA repair. The DNA sequence is a major factor influencing the position of nucleosomes on genomes. Different sequence motifs can promote or inhibit the nucleosome formation, thus influencing the accessibility to the DNA. Sequence-encoded nucleosome positioning having functional consequences on cell processes can then be selected or counter-selected during evolution. We review the interplay between sequence evolution and nucleosome positioning evolution. We first focus on the different ways to encode nucleosome positions in the DNA sequence, and to which extent these mechanisms are responsible of genome-wide nucleosome positioning in vivo. Then, we discuss the findings about selection of sequences for their nucleosomal properties. Finally, we illustrate how the nucleosome can directly influence sequence evolution through its interactions with DNA damage and repair mechanisms. This review aims to provide an overview of the mutual influence of sequence evolution and nucleosome positioning evolution, possibly leading to complex evolutionary dynamics.

Subject Areas

DNA sequence-encoded nucleosome ordering; Nucleosome depleted regions; DNS sequence mutation; Chromatin evolution.

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