Working Paper Article Version 3 This version is not peer-reviewed

The INDIA Mutations and B.1.617 Variants: Is there a Global "Strategy" for Mutations and Evolution of Variants of the SARS-CoV2 Genome?

Version 1 : Received: 23 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (20:14:21 CEST)
Version 2 : Received: 27 April 2021 / Approved: 28 April 2021 / Online: 28 April 2021 (17:18:50 CEST)
Version 3 : Received: 17 May 2021 / Approved: 18 May 2021 / Online: 18 May 2021 (14:05:33 CEST)

How to cite: Perez, J. The INDIA Mutations and B.1.617 Variants: Is there a Global "Strategy" for Mutations and Evolution of Variants of the SARS-CoV2 Genome?. Preprints 2021, 2021040689 Perez, J. The INDIA Mutations and B.1.617 Variants: Is there a Global "Strategy" for Mutations and Evolution of Variants of the SARS-CoV2 Genome?. Preprints 2021, 2021040689

Abstract

ABSTRACT. In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and 2021. We then demonstrate - both on actual genomes of patients and on variants combining the most frequent mutations to the SARS-CoV2 Wuhan genomes and then to the B.1.617 variant - that the numerical Fibonacci AU / CG metastructures increase considerably in all cases analyzed in ratios of up to 8 times. We can affirm that this property contributes to a greater stability and lifespan of messenger RNAs, therefore, possibly also to a greater INFECTUOSITY of these variant genomes. Out of a total of 108 genomes analyzed: - None ("NONE") of them contained a number of metastructures LOWER than those of the reference SARS-CoV2 Wuhan genome. - Eleven (11) among them contained the same number of metastructures as the reference genome. - 97 of them contained a GREATER number of metastructures than the reference genome, ie 89.81% of cases. The average increase in the number of metastructures for the 97 cases studied is 4.35 times the number of SARS-CoV2 UA/CG 17711 Fibonacci metastructures. Finally, we put a focus on B.1.617.2 crucial exponential growth Indian variant. Then, we demonstrate, by analyzing the main worldwide 19 variants, both at the level of spikes and of whole genomes, how and why these UA / CG metastuctures increase overall in the variants compared to the 2 reference strains SARS-CoV2 Wuhan and D614G.

Subject Areas

SARS-CoV2; Biomathematics; vaccine; variants; mRNA; Fibonacci; Indian variants; B.1.617; B.1.617.2.

Comments (2)

Comment 1
Received: 18 May 2021
Commenter: Jean-claude Perez
Commenter's Conflict of Interests: Author
Comment: page 1
Title update: "S" add to Variants
The INDIA Mutations and B.1.617 Variants: Is there a global "strategy" for mutations and evolution of variants of the SARS-CoV2 genome?
page 1
update adds to the end of abstract
Finally, we put a focus on B.1.617.2 crucial exponential growth Indian variant. Then, we demonstrate, by analyzing the main worldwide 19 variants, both at the level of spikes and of whole genomes, how and why these UA / CG metastuctures increase overall in the variants compared to the 2 reference strains SARS-CoV2 Wuhan and D614G.
page 29
add a new §  3.5
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Updates and adds to conclusion
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new references



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Response 1 to Comment 1
Received: 19 May 2021
Commenter: Valère Lounnas
The commenter has declared there is no conflict of interests.
Comment: I have read the manuscript of Jean-Claude Perez and its fascinating conclusion.

We understant that the increased number of Fibonacci metastructures may lead to a better adaptation of the virus
and, therefore, to higher infectious character, but not to necessary higher pathogenicity.

Pathogeny may indeed be related to a harmonic inadaptation of the virus, the immune system being naive to this
configuration.

However, the infectious character and pathogenicity are otherwise related.

I conclude that this virus was not harmonically natural at the beginning and tends now to become natural along
the course of the pandemy. Very fortunately, and thus one should see the end of it without the need of vaccins.
I believe collective immunity will solve the problem. It seems to me that this is what is happening despite all the efforts of our gouvernments to prevent it.


J'ai lu le manuscrit de Jean-Claude Perez avec sa conclusion passionnante.
On comprend que l'augmentation des métastructures de Fibonacci peut conduire à une meilleure adaptation du virus et donc une plus grand infectiosité, mais pas nécessairement pathogénie.

La pathogénie pourrait être en effet reliée à une inadaptation harmonique du virus, le système immunitaire étant naïf à cette configuration.

Mais pathogénie et caractère infectieux sont par ailleurs reliées.

Ce que je conclus c'est que visiblement ce virus n'était pas harmoniquement naturel à la base et tend à se naturaliser
au fil de la pandémie, fort heureusement et donc on devrait bien en voir le bout sans l'aide de vaccins. Je crois
à l'immunité collective pour résoudre le problème. Il me semble que c'est ce qui est entrain de se passer malgré
tous les efforts de nos gouvernant pour l'empêcher.

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