Version 1
: Received: 23 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (20:14:21 CEST)
Version 2
: Received: 27 April 2021 / Approved: 28 April 2021 / Online: 28 April 2021 (17:18:50 CEST)
Version 3
: Received: 17 May 2021 / Approved: 18 May 2021 / Online: 18 May 2021 (14:05:33 CEST)
How to cite:
Perez, J. The INDIA Mutations and B.1.617 Variant:Is There a Global "Strategy" for Mutations and Evolution of Variants of The SARS-CoV2 Genome?. Preprints2021, 2021040689. https://doi.org/10.20944/preprints202104.0689.v2
Perez, J. The INDIA Mutations and B.1.617 Variant: Is There a Global "Strategy" for Mutations and Evolution of Variants of The SARS-CoV2 Genome?. Preprints 2021, 2021040689. https://doi.org/10.20944/preprints202104.0689.v2
Perez, J. The INDIA Mutations and B.1.617 Variant:Is There a Global "Strategy" for Mutations and Evolution of Variants of The SARS-CoV2 Genome?. Preprints2021, 2021040689. https://doi.org/10.20944/preprints202104.0689.v2
APA Style
Perez, J. (2021). The INDIA Mutations and B.1.617 Variant:<i> </i>Is There a Global "Strategy" for Mutations and Evolution of Variants of The SARS-CoV2 Genome?. Preprints. https://doi.org/10.20944/preprints202104.0689.v2
Chicago/Turabian Style
Perez, J. 2021 "The INDIA Mutations and B.1.617 Variant:<i> </i>Is There a Global "Strategy" for Mutations and Evolution of Variants of The SARS-CoV2 Genome?" Preprints. https://doi.org/10.20944/preprints202104.0689.v2
Abstract
ABSTRACT. In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and 2021. We then demonstrate - both on actual genomes of patients and on variants combining the most frequent mutations to the SARS-CoV2 Wuhan genomes and then to the B.1.617 variant - that the numerical Fibonacci AU / CG metastructures increase considerably in all cases analyzed in ratios of up to 8 times. We can affirm that this property contributes to a greater stability and lifespan of messenger RNAs, therefore, possibly also to a greater INFECTUOSITY of these variant genomes. Out of a total of 108 genomes analyzed: - None ("NONE") of them contained a number of metastructures LOWER than those of the reference SARS-CoV2 Wuhan genome. - Eleven (11) among them contained the same number of metastructures as the reference genome. - 97 of them contained a GREATER number of metastructures than the reference genome, ie 89.81% of cases.The average increase in the number of metastructures for the 97 cases studied is 4.35 times the number of SARS-CoV2 UA/CG 17711 Fibonacci metastructures.
Keywords
SARS-CoV2; Biomathematics; vaccine; variants; mRNA; Fibonacci; Indian variants; B.1.617
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
28 April 2021
Commenter:
Jean-claude Perez
Commenter's Conflict of Interests:
Author
Comment:
update abstract: ABSTRACT. In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and 2021. We then demonstrate - both on actual genomes of patients and on variants combining the most frequent mutations to the SARS-CoV2 Wuhan genomes and then to the B.1.617 variant - that the numerical Fibonacci AU / CG metastructures increase considerably in all cases analyzed in ratios of up to 8 times. We can affirm that this property contributes to a greater stability and lifespan of messenger RNAs, therefore, possibly also to a greater INFECTUOSITY of these variant genomes. Out of a total of 108 genomes analyzed: - None ("NONE") of them contained a number of metastructures LOWER than those of the reference SARS-CoV2 Wuhan genome. - Eleven (11) among them contained the same number of metastructures as the reference genome. - 97 of them contained a GREATER number of metastructures than the reference genome, ie 89.81% of cases.The average increase in the number of metastructures for the 97 cases studied is 4.35 times the number of SARS-CoV2 UA/CG 17711 Fibonacci metastructures.
Commenter: Jean-claude Perez
Commenter's Conflict of Interests: Author
ABSTRACT.
In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and 2021. We then demonstrate - both on actual genomes of patients and on variants combining the most frequent mutations to the SARS-CoV2 Wuhan genomes and then to the B.1.617 variant - that the numerical Fibonacci AU / CG metastructures increase considerably in all cases analyzed in ratios of up to 8 times. We can affirm that this property contributes to a greater stability and lifespan of messenger RNAs, therefore, possibly also to a greater INFECTUOSITY of these variant genomes. Out of a total of 108 genomes analyzed: - None ("NONE") of them contained a number of metastructures LOWER than those of the reference SARS-CoV2 Wuhan genome. - Eleven (11) among them contained the same number of metastructures as the reference genome. - 97 of them contained a GREATER number of metastructures than the reference genome, ie 89.81% of cases. The average increase in the number of metastructures for the 97 cases studied is 4.35 times the number of SARS-CoV2 UA/CG 17711 Fibonacci metastructures.
and add anew chapter page 20.