Submitted:
20 April 2021
Posted:
22 April 2021
Read the latest preprint version here
Abstract
Larger-scale integration (LSI) resides at the heart of comprehensive sample-to-answer automation and parallelisation of assay panels for frequent and ubiquitous bioanalytical testing in decentralised the point-of-use / point-of-care settings. With an emphasis on rotational, centrifugo-pneumatic flow control, this paper employs a virtual “digital twin” strategy, considering experimental tolerances, to efficiently design such “Lab-on-a-Disc” systems featuring high packing density, reliability, configurability, modularity, manufacturability, performance while minimizing development and fabrication cost.
Keywords:
centrifugal microfluidics
; Lab-on-a-Disc
; centrifugo-pneumatic flow control
; integration
; multiplexing
; parallelization
; sample-to-answer
; reliability
; tolerances
; design-for-manufacture
; digital twin
; event-triggering
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
