Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of the Novel Culture-Based AtbFinder Test-System for the Selection of Optimal Antibiotics for Critically Ill Patients With Polymicrobial Infections Within 4 H

Version 1 : Received: 13 April 2021 / Approved: 14 April 2021 / Online: 14 April 2021 (14:21:15 CEST)

A peer-reviewed article of this Preprint also exists.

Tetz, G.; Tetz, V. Evaluation of a New Culture-Based AtbFinder Test-System Employing a Novel Nutrient Medium for the Selection of Optimal Antibiotics for Critically Ill Patients with Polymicrobial Infections within 4 h. Microorganisms 2021, 9, 990. Tetz, G.; Tetz, V. Evaluation of a New Culture-Based AtbFinder Test-System Employing a Novel Nutrient Medium for the Selection of Optimal Antibiotics for Critically Ill Patients with Polymicrobial Infections within 4 h. Microorganisms 2021, 9, 990.

Journal reference: Microorganisms 2021, 9, 990
DOI: 10.3390/microorganisms9050990

Abstract

For polymicrobial infections, AtbFinder utilizes a novel paradigm of the population response to antibiotics, enabling bacterial growth in the form of a mixed microbial community and selecting the antibiotics targeting not only the principal pathogen, but also those bacteria that support their growth. TGV medium allowed culturing a more diverse set of bacteria from polymicrobial biospecimens, compared with that achieved with the standard media and enabled, already within 4h, accurate selection of the antibiotics that completely eliminated all cultivatable bacteria from clinical samples. In conclusion, AtbFinder system may be a valuable tool in improving antibiotic selection, enabling targeted empirical therapy and accurate antibiotic replacement, which is especially important in high-risk patients.

Subject Areas

antibiotic resistance; antimicrobial susceptibility testing; novel diagnostics; polymicrobial; sputum; drug resistant

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