Working Paper Review Version 1 This version is not peer-reviewed

The Present and Future of Neoadjuvant Endocrine Therapy for Breast Cancer Treatment

Version 1 : Received: 8 April 2021 / Approved: 12 April 2021 / Online: 12 April 2021 (13:55:10 CEST)

A peer-reviewed article of this Preprint also exists.

Martí, C.; Sánchez-Méndez, J.I. The Present and Future of Neoadjuvant Endocrine Therapy for Breast Cancer Treatment. Cancers 2021, 13, 2538. Martí, C.; Sánchez-Méndez, J.I. The Present and Future of Neoadjuvant Endocrine Therapy for Breast Cancer Treatment. Cancers 2021, 13, 2538.

Journal reference: Cancers 2021, 13, 2538
DOI: 10.3390/cancers13112538

Abstract

Endocrine therapy (ET) has established itself as an efficacious treatment for estrogen receptor-positive (ER+) breast cancers, with a reduction in recurrence rates and increased survival rates. The pre-surgical approach with chemotherapy (NCT) has become a common form of management for large, locally advanced or high-risk tumors. However, a good response to NCT is not usually expected in ER+ tumors. Good results with primary ET, mainly in elderly women, have encouraged studies in other stages of life, and nowadays neoadjuvant endocrine treatment (NET) has become a useful approach to many ER+ breast cancers. The aim of this review is to provide an update on the current state of art regarding the present and the future role of NET.

Keywords

breast cancer; endocrine therapy; neoadjuvant; resistance

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