Working Paper Article Version 1 This version is not peer-reviewed

Baseline Levels of Vitamin D in a Healthy Population from a Region with High Solar Irradiation

Version 1 : Received: 7 April 2021 / Approved: 8 April 2021 / Online: 8 April 2021 (12:17:33 CEST)

A peer-reviewed article of this Preprint also exists.

García-Dorta, A.; Medina-Vega, L.; Villacampa-Jiménez, J.J.; Hernández-Díaz, M.; Bustabad-Reyes, S.; González-Dávila, E.; Díaz-González, F. Baseline Levels of Vitamin D in a Healthy Population from a Region with High Solar Irradiation. Nutrients 2021, 13, 1647. García-Dorta, A.; Medina-Vega, L.; Villacampa-Jiménez, J.J.; Hernández-Díaz, M.; Bustabad-Reyes, S.; González-Dávila, E.; Díaz-González, F. Baseline Levels of Vitamin D in a Healthy Population from a Region with High Solar Irradiation. Nutrients 2021, 13, 1647.

Journal reference: Nutrients 2021, 13, 1647
DOI: 10.3390/nu13051647

Abstract

The use of vitamin D (VitD) supplements has become widespread in the last decade due not only to the dissociation between the blood levels recommended as "optimal" and those shown by the healthy population, but also to its presumed beneficial effects on multiple disorders. This work evaluated the levels of 25-hydroxyvitamin D [25(OH)D] in a healthy population of European origin living in a region with high solar irradiation. In serum samples from a population-based study conducted in the Canary Islands, levels of 25(OH)D were analyzed. In 876 individuals who had no history of kidney or malabsorption disorders and who had not been treated with calcium and/or VitD supplementation, the median 25(OH)D level was 26.3 (5th;95th percentile, 14.3;45.8)ng/mL. Notably, 65.4% of the population had 25(OH)D blood levels below 30ng/mL, 23.4% below 20ng/mL and 6.4% below 15ng/mL. Based on the lack of evidence supporting causality between 25(OH)D levels below what is recommended as optimal (≥20ng/mL, or even ≥30ng/mL) and major skeletal and non-skeletal diseases, and in light of the distribution of the concentration of this vitamin in healthy adults living under optimal conditions of solar irradiation, it seems reasonable to consider 25(OH)D levels below 20ng/mL and close to 15ng/mL as adequate for the general population.

Keywords

Vitamin D levels; population-based distribution; healthy adults; high solar irradiation.

Subject

MEDICINE & PHARMACOLOGY, General Medical Research

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