Version 1
: Received: 31 March 2021 / Approved: 1 April 2021 / Online: 1 April 2021 (17:32:58 CEST)
Version 2
: Received: 6 April 2021 / Approved: 7 April 2021 / Online: 7 April 2021 (10:13:48 CEST)
Version 3
: Received: 12 April 2021 / Approved: 12 April 2021 / Online: 12 April 2021 (16:19:44 CEST)
Version 4
: Received: 15 April 2021 / Approved: 15 April 2021 / Online: 15 April 2021 (14:07:15 CEST)
Version 5
: Received: 19 April 2021 / Approved: 20 April 2021 / Online: 20 April 2021 (10:05:55 CEST)
How to cite:
Perez, J. SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures. Preprints2021, 2021040034. https://doi.org/10.20944/preprints202104.0034.v2
Perez, J. SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures. Preprints 2021, 2021040034. https://doi.org/10.20944/preprints202104.0034.v2
Perez, J. SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures. Preprints2021, 2021040034. https://doi.org/10.20944/preprints202104.0034.v2
APA Style
Perez, J. (2021). SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures. Preprints. https://doi.org/10.20944/preprints202104.0034.v2
Chicago/Turabian Style
Perez, J. 2021 "SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures" Preprints. https://doi.org/10.20944/preprints202104.0034.v2
Abstract
In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 8 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes.5/ Toward a meta mRNA Fibonacci gene end message code.6/ analysing S501 UK, S484 South Afrika and 2 mutations IINDIA variants.7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFITZER and MODERNA. Particularly, we suggest the following conjecture at mRNA folding level: CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of podiums for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a hairpin, which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==> UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME..
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
7 April 2021
Commenter:
Jean-claude Perez
Commenter's Conflict of Interests:
Author
Comment:
§8 was totally changed with more details: pages 44 to 51 of the release2 article. Summary and conclusion are updated by: " Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==> UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME.."
Commenter: Jean-claude Perez
Commenter's Conflict of Interests: Author
pages 44 to 51 of the release2 article.
Summary and conclusion are updated by:
" Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==> UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME.."