Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Semi-Supervised Learning in Medical Image Segmentation: Brain Tissue with White Matter Hyperintensity Segmentation Using FLAIR Image

Version 1 : Received: 31 March 2021 / Approved: 1 April 2021 / Online: 1 April 2021 (10:01:05 CEST)

A peer-reviewed article of this Preprint also exists.

Rieu, Z.; Kim, J.; Kim, R.E.; Lee, M.; Lee, M.K.; Oh, S.W.; Wang, S.-M.; Kim, N.-Y.; Kang, D.W.; Lim, H.K.; Kim, D. Semi-Supervised Learning in Medical MRI Segmentation: Brain Tissue with White Matter Hyperintensity Segmentation Using FLAIR MRI. Brain Sci. 2021, 11, 720. Rieu, Z.; Kim, J.; Kim, R.E.; Lee, M.; Lee, M.K.; Oh, S.W.; Wang, S.-M.; Kim, N.-Y.; Kang, D.W.; Lim, H.K.; Kim, D. Semi-Supervised Learning in Medical MRI Segmentation: Brain Tissue with White Matter Hyperintensity Segmentation Using FLAIR MRI. Brain Sci. 2021, 11, 720.

Journal reference: Brain Sci. 2021, 11, 720
DOI: 10.3390/brainsci11060720

Abstract

White matter hyperintensity (WMH) has been considered the primary biomarker from small-vessel cerebrovascular disease to Alzheimer’s disease (AD) and has been reported for its correlation of brain structural changes. To perform WMH related analysis with brain structure, both T1-weighted (T1w) and (Fluid Attenuated Inversion Recovery(FLAIR) are required. However, in a clinical situation, it is limited to obtain 3D T1w and FLAIR images simultaneously. Also, the most of brain segmentation technique supports 3D T1w only. Therefore, we introduced the semi-supervised learning method that can perform brain segmentation using FLAIR image only. Our method achieved a dice overlap score of 0.86 for brain tissue segmentation on FLAIR, with the relative volume difference between T1w and FLAIR segmentation under 4.8%, which is just as reliable as the segmentation done by its paired T1w image. We believe our semi-supervised learning method has a great potential to be used to other MRI sequences and provide encouragement to people who seek brain tissue segmentation from a non-T1w image.

Keywords

segmentation; deep-learning; FLAIR; T1w; white matter hyperintensity

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