Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Sandeep Appunni
,
Muni Rubens
ORCID logo ,
Venkataraghavan Ramamoorthy
,
Anshul Saxena
,
Raees Tonse
,
Peter McGranaghan
,
Adeel Kaiser
,
Rupesh Kotecha
*
Version 1 : Received: 26 March 2021 / Approved: 29 March 2021 / Online: 29 March 2021 (22:22:00 CEST)

How to cite: Appunni, S.; Rubens, M.; Ramamoorthy, V.; Saxena, A.; Tonse, R.; McGranaghan, P.; Kaiser, A.; Kotecha, R. Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer. Preprints 2021, 2021030712. https://doi.org/10.20944/preprints202103.0712.v1 Appunni, S.; Rubens, M.; Ramamoorthy, V.; Saxena, A.; Tonse, R.; McGranaghan, P.; Kaiser, A.; Kotecha, R. Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer. Preprints 2021, 2021030712. https://doi.org/10.20944/preprints202103.0712.v1

Abstract

Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present evidence regarding the relationship of dietary factors to the gut microbiome and development of CRC.

Keywords

dietary fibers; short chain fatty acid; gut microbiota; colorectal cancer prevention; epigenetics

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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