Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Novel Diagnostic Markers for Endometriosis

Version 1 : Received: 20 March 2021 / Approved: 22 March 2021 / Online: 22 March 2021 (15:41:10 CET)

How to cite: Kimber-Trojnar, Ż.; Pilszyk, A.; Niebrzydowska, M.; Pilszyk, Z.; Ruszała, M.; Leszczyńska-Gorzelak, B. Novel Diagnostic Markers for Endometriosis. Preprints 2021, 2021030544. https://doi.org/10.20944/preprints202103.0544.v1 Kimber-Trojnar, Ż.; Pilszyk, A.; Niebrzydowska, M.; Pilszyk, Z.; Ruszała, M.; Leszczyńska-Gorzelak, B. Novel Diagnostic Markers for Endometriosis. Preprints 2021, 2021030544. https://doi.org/10.20944/preprints202103.0544.v1

Abstract

Endometriosis is a disease that affects women of reproductive age and has a significant impact on their well-being. The main symptoms are dysmenorrhea, chronic pelvic pain and infertility. The diagnostic process in many cases is very long and can take up to 8-12 years. Laparoscopy, which is an invasive method, is still necessary to confirm final identification. Therefore, the development of diagnostic markers seems to be crucial for the diagnosis and proper treatment of women affected by endometriosis as soon as possible. Still the most frequently studied and used marker is Cancer Antigen 125 (CA-125). Other glycoproteins, growth factors and immune markers seem to play an important role. However, the search for the ideal endometriosis marker is still ongoing. Developing researches on endometriosis pathogenesis help to identify potential biomarkers or sets of biomarkers in order to improve and speed up the diagnostic process in a non-invasive way.

Keywords

endometriosis; diagnostic markers; CA-125; urocortin; activin A; follistatin; microRNA; integrins

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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