Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Colombian Essential oil of Ruta Graveolens Against Candida sp. Isolated from the Oral Cavity of Patients with Head and Neck Cancer

Version 1 : Received: 3 March 2021 / Approved: 4 March 2021 / Online: 4 March 2021 (09:18:46 CET)

How to cite: Donadu, M.G.; Peralta-Ruiz, Y.; Usai, D.; Maggio*, F.; Rizzo, D.; Bussu, F.; Rubino, S.; Zanetti, S.; Paparella, A.; Lopez*, C.C. Colombian Essential oil of Ruta Graveolens Against Candida sp. Isolated from the Oral Cavity of Patients with Head and Neck Cancer. Preprints 2021, 2021030147 (doi: 10.20944/preprints202103.0147.v1). Donadu, M.G.; Peralta-Ruiz, Y.; Usai, D.; Maggio*, F.; Rizzo, D.; Bussu, F.; Rubino, S.; Zanetti, S.; Paparella, A.; Lopez*, C.C. Colombian Essential oil of Ruta Graveolens Against Candida sp. Isolated from the Oral Cavity of Patients with Head and Neck Cancer. Preprints 2021, 2021030147 (doi: 10.20944/preprints202103.0147.v1).

Abstract

The problem of drug resistance in terms of antifungal therapy, unknown until a few years ago, is assuming increasing importance. Particularly in immunosuppressed patients and subject to chemotherapy and radiotherapy. In the last years the use of essential oils as approach to improving the effectiveness of antifungal agents and reducing the antibiotic resistant has been proposed. Our research aimed to evaluate the antifungal activity of Colombian essential oil of Ruta graveolens (REO) against clinical strains of Candida albicans, Candida parapsilopsis, C. glabrata and Candida tropicalis. The data obtained showed that Candida tropicalis and Candida albicans were most sensible strains showing minimum inhibitory concentrations (MIC) of 0.5 and 1.0 µg/ml of REO. The Time Kill Kinetics assay demonstrated that REO showed fungicide effect against C. tropicalis and fungistatic effect against C. albicans. In addition, the 40% of the biofilm formed by C. albicans was eradicated using 1% of REO after 1 hour of exposure.

Subject Areas

Candida sp.; head - neck tumor; innovative antifungals; azole-resistant; Ruta graveolens.

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