Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Memory Generation and Re-Activation in Food Allergy

Version 1 : Received: 2 March 2021 / Approved: 3 March 2021 / Online: 3 March 2021 (11:36:33 CET)
Version 2 : Received: 1 May 2021 / Approved: 5 May 2021 / Online: 5 May 2021 (12:38:46 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Immunotargets and Therapy 2021, 10, 171-184
DOI: 10.2147/ITT.S284823

Abstract

Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG+ memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. The newly identified Th2A and Tfh13 populations represent a leap in our understanding of allergen-specific T cell phenotypes, though how these populations contribute to IgE memory responses remains poorly understood. Within, we discuss the mechanisms by which memory B and T cells are activated, integrating knowledge from human systems and fundamental research. We then focus on memory reactivation; specifically, on the pathways of secondary IgE responses. Throughout, we identify areas of future research which will help identify immunotargets for a transformative therapy for food allergy.

Keywords

food allergy; IgE; memory responses; anaphylaxis; B cells; T cells;

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