This version is not peer-reviewed
Memory Generation and Re-Activation in Food Allergy
: Received: 2 March 2021 / Approved: 3 March 2021 / Online: 3 March 2021 (11:36:33 CET)
: Received: 1 May 2021 / Approved: 5 May 2021 / Online: 5 May 2021 (12:38:46 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: Immunotargets and Therapy 2021, 10, 171-184
Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG+ memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. The newly identified Th2A and Tfh13 populations represent a leap in our understanding of allergen-specific T cell phenotypes, though how these populations contribute to IgE memory responses remains poorly understood. Within, we discuss the mechanisms by which memory B and T cells are activated, integrating knowledge from human systems and fundamental research. We then focus on memory reactivation; specifically, on the pathways of secondary IgE responses. Throughout, we identify areas of future research which will help identify immunotargets for a transformative therapy for food allergy.
food allergy; IgE; memory responses; anaphylaxis; B cells; T cells;
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.