Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study

Version 1 : Received: 27 February 2021 / Approved: 1 March 2021 / Online: 1 March 2021 (13:45:51 CET)

How to cite: Song, Y.; Yu, S.; He, X.; Yang, L.; Wu, Y.; Qin, G.; Zhang, Q.; Talwar, G.D.S.; Xu, L.; Moore, J.E.; He, W.; Pazo, E.E. Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study. Preprints 2021, 2021030017 (doi: 10.20944/preprints202103.0017.v1). Song, Y.; Yu, S.; He, X.; Yang, L.; Wu, Y.; Qin, G.; Zhang, Q.; Talwar, G.D.S.; Xu, L.; Moore, J.E.; He, W.; Pazo, E.E. Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study. Preprints 2021, 2021030017 (doi: 10.20944/preprints202103.0017.v1).

Abstract

Background: Inadequate meibomian glands (MGs) secretion can lead to dry eye signs and symptoms. Tear film lipid layer (TFLL) secreted by MGs protects and prevents rapid evaporation of tear film. Our purpose was to assess TFLL alteration and function in patients with evaporative dry eye (EDE) using tear interferometry after optimal pulse light technology (OPT) intense pulsed light (IPL). Methods: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month. Results: At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P<0.05) in the IPL group, while the sham group had no significant improvements. All DE parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards. Conclusion: IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears usage.

Keywords

dry eye disease; meibomian gland; tear stability; tear film lipid layer; interferometry; OSDI; intense pulse light; IPL

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