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Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study
Song, Y.; Yu, S.; He, X.; Yang, L.; Wu, Y.; Qin, G.; Zhang, Q.; Talwar, G.D.S.; Xu, L.; Moore, J.E.; He, W.; Pazo, E.E. Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study. Preprints2021, 2021030017. https://doi.org/10.20944/preprints202103.0017.v1
APA Style
Song, Y., Yu, S., He, X., Yang, L., Wu, Y., Qin, G., Zhang, Q., Talwar, G.D.S., Xu, L., Moore, J.E., He, W., & Pazo, E.E. (2021). Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study. Preprints. https://doi.org/10.20944/preprints202103.0017.v1
Chicago/Turabian Style
Song, Y., Wei He and Emmanuel Eric Pazo. 2021 "Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study" Preprints. https://doi.org/10.20944/preprints202103.0017.v1
Abstract
Background: Inadequate meibomian glands (MGs) secretion can lead to dry eye signs and symptoms. Tear film lipid layer (TFLL) secreted by MGs protects and prevents rapid evaporation of tear film. Our purpose was to assess TFLL alteration and function in patients with evaporative dry eye (EDE) using tear interferometry after optimal pulse light technology (OPT) intense pulsed light (IPL). Methods: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month. Results: At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P<0.05) in the IPL group, while the sham group had no significant improvements. All DE parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards. Conclusion: IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears usage.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
