Working Paper Review Version 1 This version is not peer-reviewed

How Can a Polymeric Formula Induce Remission in Crohn Disease Patients?

Version 1 : Received: 15 February 2021 / Approved: 16 February 2021 / Online: 16 February 2021 (15:58:08 CET)

How to cite: Boumessid, K.; Barreau, F.; Mas, E. How Can a Polymeric Formula Induce Remission in Crohn Disease Patients?. Preprints 2021, 2021020341 Boumessid, K.; Barreau, F.; Mas, E. How Can a Polymeric Formula Induce Remission in Crohn Disease Patients?. Preprints 2021, 2021020341

Abstract

Crohn’s disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, the dietary therapy with exclusive enteral nutrition is recommended as first line option, at least for children, because it induces clinical remission and mucosal healing. Modulen®, a polymeric TGF-β2 enriched formula, has a good palatability and is widely used. For the first time in the literature, this review outlines and discusses the clinical outcomes obtained with this therapy, as well as the potential mechanisms of action of its compounds. It can be explained by its TGF-β2 content but also by its protein and lipid composition. Further well-designed studies are required to improve our knowledge and to optimize therapeutic strategies.

Keywords

Crohn’s Disease, Inflammatory Bowel Disease, Exclusive Enteral Nutrition, Mucosal Healing

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