Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Post Stroke Depression to be Expected

Version 1 : Received: 10 February 2021 / Approved: 11 February 2021 / Online: 11 February 2021 (16:46:06 CET)

A peer-reviewed article of this Preprint also exists.

Wijeratne, T.; Sales, C. Understanding Why Post-Stroke Depression May Be the Norm Rather Than the Exception: The Anatomical and Neuroinflammatory Correlates of Post-Stroke Depression. J. Clin. Med. 2021, 10, 1674. Wijeratne, T.; Sales, C. Understanding Why Post-Stroke Depression May Be the Norm Rather Than the Exception: The Anatomical and Neuroinflammatory Correlates of Post-Stroke Depression. J. Clin. Med. 2021, 10, 1674.

Journal reference: J. Clin. Med. 2021, 10, 1674
DOI: 10.3390/jcm10081674

Abstract

Ischemic Stroke precedes depression . Post Stroke Depression (PSD) is a major driver for poor recovery, negative quality of life, poor rehabilitation outcomes and poor functional ability. This systematic reviews confirmed the post stroke depression as the norm as complex ischemic cascade involve the bioenergetic failure, deranged iron homeostasis ( calcium influx, Na influx, potassium efflux etc) excitotoxicity, acidotoxicity,disruption of the blood brain barrier, cytokine mediated cytotoxicity, reactive oxygen mediated toxicity , activation of cyclooxygenase pathway and generation of toxic products, infiltration of immune mediated cells resulting the cell death and deranged neuronal networks in mood related brain regions. This review focus on the pathobiology of stroke in the context and make the argument that PSD is the norm after a stroke rather than the exception.

Subject Areas

Cytokine, Depression, Ischemia, Stroke, Apoptosis, Excitotoxicity, Onecosis, Inflammation,

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