Azevedo, L.; Correia, A.; Almeida, C.F.; Molinero-Mourelle, P.; Correia, M.; Del Río Highsmith, J. Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial. Int. J. Environ. Res. Public Health2021, 18, 3398.
Azevedo, L.; Correia, A.; Almeida, C.F.; Molinero-Mourelle, P.; Correia, M.; Del Río Highsmith, J. Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial. Int. J. Environ. Res. Public Health 2021, 18, 3398.
Journal reference: Int. J. Environ. Res. Public Health 2021, 18, 3398 DOI: 10.3390/ijerph18073398
Cite as:
Azevedo, L.; Correia, A.; Almeida, C.F.; Molinero-Mourelle, P.; Correia, M.; Del Río Highsmith, J. Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial. Int. J. Environ. Res. Public Health2021, 18, 3398.
Azevedo, L.; Correia, A.; Almeida, C.F.; Molinero-Mourelle, P.; Correia, M.; Del Río Highsmith, J. Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial. Int. J. Environ. Res. Public Health 2021, 18, 3398.
Abstract
To assess the clinical efficacy of a novel organic olive oil-based denture adhesive and its effect on Candida Albicans growth in maxillary edentulous individuals wearing complete dentures. Individuals were selected from two Dental Schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (Test) was compared with a commercialized adhesive (Control) and Vaseline (Placebo) randomly assigned in a cross-study design. The retention resistance was measured with a Gnathometer and a dynamometer, the patient related outcome evaluations with a 5-points questionnaire and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium in order to evaluate differences between the placebo and experimental product. Twenty-three participants were included. Dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = .03; control, p = .04), no significant differences between the two adhesives (p > .05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = .001); the control reported better results at taste (p = .03) in chewing (p = .001). The test adhesive showed better (p < .001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and placebo with a better inhibition capacity for the growth of Candida albicans, patients reported better abilities for speech, chewing, taste and retirement in the control adhesive.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Luís Azevedo
,
Carlos F. Almeida