Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Planckian Distribution Equation As A Novel Method To Predict The Efficacy Of Breast Cancer Pharmacotherapy

Version 1 : Received: 5 February 2021 / Approved: 8 February 2021 / Online: 8 February 2021 (16:00:22 CET)

How to cite: Rajan, S. The Planckian Distribution Equation As A Novel Method To Predict The Efficacy Of Breast Cancer Pharmacotherapy. Preprints 2021, 2021020216 (doi: 10.20944/preprints202102.0216.v1). Rajan, S. The Planckian Distribution Equation As A Novel Method To Predict The Efficacy Of Breast Cancer Pharmacotherapy. Preprints 2021, 2021020216 (doi: 10.20944/preprints202102.0216.v1).

Abstract

Chemotherapy-related deaths, the result of treatment with faulty medications, account for nearly 10% of all breast cancer deaths (Rashbass, 2016). Patient-specific, personalized medicine is evidently required to administer optimized therapeutics and prevent treatment-related mortality. In order to develop a predictive model for breast cancer therapy, the following study analyzed the mRNA data of 4,704 genes derived from 20 breast cancer patients before and after doxorubicin treatment for 16 weeks (O’brien et al., 2006; Perou et al., 2000). The genomic data of each patient was first stratified into 9 groups (corresponding to the 9 Mechanisms defined in Figure 4) based on mRNA expression in response to the tumor and to the doxorubicin treatment. The study then employed the Planckian Distribution Equation (PDE) discovered at Rutgers University to model the stratified samples by transforming each mechanism into a single long-tailed histogram fitted by the PDE. Our PDE model is based on 3 parameters - A, B, and C - of which 2 were extracted from each model to generate the plots seen in figures 5e and 5f. The drug-induced slopes of the A vs C plots were then determined for all 9 mechanisms of each patient. The study observed an increase in post-treatment mRNA levels for longer surviving patients in 6 mechanisms. Further analysis displayed how the drug treatment uniquely altered each of the mechanisms based on the length of patient survival. These results indicate that the PDE-based procedures described herein may provide a novel tool for discovering potential anti-breast cancer pharmaceuticals.

Keywords

Planckian Distribution Equation; breast cancer; mRNA; chemotherapy

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