Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Tissue Engineering Strategies for Retinal Regeneration

Version 1 : Received: 6 February 2021 / Approved: 8 February 2021 / Online: 8 February 2021 (10:46:50 CET)

A peer-reviewed article of this Preprint also exists.

Nair, D.S.R.; Seiler, M.J.; Patel, K.H.; Thomas, V.; Camarillo, J.C.M.; Humayun, M.S.; Thomas, B.B. Tissue Engineering Strategies for Retina Regeneration. Appl. Sci. 2021, 11, 2154. Nair, D.S.R.; Seiler, M.J.; Patel, K.H.; Thomas, V.; Camarillo, J.C.M.; Humayun, M.S.; Thomas, B.B. Tissue Engineering Strategies for Retina Regeneration. Appl. Sci. 2021, 11, 2154.

Journal reference: Appl. Sci. 2021, 11, 2154
DOI: 10.3390/app11052154

Abstract

The retina is a complex and fragile photosensitive part of the central nervous system which is prone to degenerative diseases leading to permanent vision loss. No proven treatment strategies exist to treat or reverse the degenerative conditions. Recent investigations demonstrate that cell transplantation therapies to replace the dysfunctional retinal pigment epithelial (RPE) cells and or the degenerating photoreceptors (PRs) are viable options to restore vision. Pluripotent stem cells, retinal progenitor cells and somatic stem cells are the main cell sources used for cell transplantation therapies. The success of retinal transplantation based on cell suspension injection is hindered by limited cell survival and lack of cellular integration. Recent advances in material science helped to develop strategies to grow cells as intact monolayers or as sheets on biomaterial scaffolds for transplantation into the eyes. Such implants are found to be more promising than the bolus injection approach. Tissue engineering techniques are specifically designed to construct biodegradable or non-degradable polymer scaffolds to grow cells as a monolayer and construct implantable grafts. The engineered cell construct along with the extracellular matrix formed, can hold the cells in place to enable easy survival, better integration and improved visual function. This article reviews the advances in the use of scaffolds for transplantation studies in animal models and its application in current clinical trials.

Keywords

Retinal degenerative diseases; Age related macular degeneration; Biomaterials, Stem cells, Retinal pigment epithelium; Tissue engineering

Subject

MATERIALS SCIENCE, Biomaterials

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.