Working Paper Article Version 2 This version is not peer-reviewed

Effects and Risk Assessment of the Polycyclic Musk Compounds Galaxolide® and Tonalide® on Marine Microalgae, Invertebrates, and Fish

Version 1 : Received: 3 February 2021 / Approved: 4 February 2021 / Online: 4 February 2021 (13:10:01 CET)
Version 2 : Received: 11 February 2021 / Approved: 11 February 2021 / Online: 11 February 2021 (13:23:39 CET)

A peer-reviewed article of this Preprint also exists.

Ehiguese, F.O.; González-Delgado, M.J.; Garrido-Perez, C.; Araújo, C.V.M.; Martin-Diaz, M.L. Effects and Risk Assessment of the Polycyclic Musk Compounds Galaxolide® and Tonalide® on Marine Microalgae, Invertebrates, and Fish. Processes 2021, 9, 371. Ehiguese, F.O.; González-Delgado, M.J.; Garrido-Perez, C.; Araújo, C.V.M.; Martin-Diaz, M.L. Effects and Risk Assessment of the Polycyclic Musk Compounds Galaxolide® and Tonalide® on Marine Microalgae, Invertebrates, and Fish. Processes 2021, 9, 371.

Journal reference: Processes 2021, 9, 371
DOI: 10.3390/pr9020371

Abstract

The current research investigated the environmental risk of the polycyclic musk compounds, Galaxolide® (HHCB) and Tonalide® (AHTN), in the marine environments. These substances are lipophilic, bioaccumulated and potentially biomagnified in aquatic organisms. To understand the toxicity of HHCB and AHTN, we performed acute toxicity tests by exposing marine microalgae (Phaeodactylum tricornutum, Tretraselmis chuii and Isochrysis galbana), crustaceans (Artemia franciscana), echinoderms (Paracentrotus lividus), bivalves (Mytilus galloprovincialis), fish (Sparus aurata) and a candidate freshwater microalga (Raphidocelis subcapitata) to environmentally relevant concentrations (0.005 - 5 µg/L) following standardized protocols. The effects of both substances on microalgae growth were incipient and only I. galbana was sensitive to HHCB and AHTN, with IC10 values of 5.22 µg/L and 0.328 µg/L, respectively. Significant (p < 0.01) concentration dependent responses were measured in P. lividus and M. galloprovincialis larvae developments as well as S. aurata mortality tested with HHCB. The effect of HHCB on P. lividus larvae development was the most sensitive endpoint recorded, producing an EC50 value of 4.07 µg/L. Our results show that HHCB represents a high risk to P. lividus larvae development for early life stages in marine environments.

Subject Areas

environmental risk assessment; polycyclic musk compounds; acute toxicity; growth inhibition; larvae development

Comments (1)

Comment 1
Received: 11 February 2021
Commenter: Friday Ehiguese
Commenter's Conflict of Interests: Author
Comment: The entire manuscript has been revised and data updated and rediscussed following reviewers' comments.
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