Working Paper Article Version 1 This version is not peer-reviewed

Impact of Dietary Potassium Nitrate on the Life Span on Drosophila Melanogaster

Version 1 : Received: 29 January 2021 / Approved: 29 January 2021 / Online: 29 January 2021 (14:20:31 CET)

How to cite: Liubertas, T.; Poderis, L.J.; Zigmantaite, V.; Capkauskiene, S.; Viskelis, P. Impact of Dietary Potassium Nitrate on the Life Span on Drosophila Melanogaster. Preprints 2021, 2021010627 Liubertas, T.; Poderis, L.J.; Zigmantaite, V.; Capkauskiene, S.; Viskelis, P. Impact of Dietary Potassium Nitrate on the Life Span on Drosophila Melanogaster. Preprints 2021, 2021010627

Abstract

The recently defined and yet rather new topic of Healthy aging is gathering more attention on the global stage. With world’s population getting older - it is rapidly becoming very important to develop and maintain functional abilities in older age and develop mechanisms to protect senior population from chronic diseases. One of the most effective components, as well as, one may call - process involved in, and strongly associated with aging is recently discovered and Nobel prize awarded - nitric oxide as a signaling molecule, which followed by later discoveries showed to have a positive metabolic, immune and anti-inflammatory effects. One of the most debated topics of the last decade in the scientific community is nitrates, one of the pathways involved in nitric oxide production. Thus, the objective of this study was to evaluate effect of different potassium nitrate concentrate supplementation on Drosophila melanogaster longevity. 0,5-3% potassium nitrate medium was analyzed on the life span and motor function in different groups consisting of 100 females fruit flies each. In this assay, female fly species supplemented with potassium nitrate diet showed life span increase by 18.6% and 5.1% with 1% and 2% KNO3- respectively with a positive impact on locomotor function. In conclusion, we found that low concentration of potassium nitrate medium increased lifespan and locomotor function in Drosophila melanogaster.

Subject Areas

nitric oxide; nitrates; dietary potassium nitrate; Drosophila melanogaster; longevity; lifespan

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