Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Licensed Anti-Microbial Drugs Logical for Clinical Trials Against Pathogens Currently Suspected in Alzheimer's Disease

Version 1 : Received: 28 January 2021 / Approved: 29 January 2021 / Online: 29 January 2021 (13:57:18 CET)

A peer-reviewed article of this Preprint also exists.

Norins, L.C. Licensed Anti-Microbial Drugs Logical for Clinical Trials against Pathogens Currently Suspected in Alzheimer’s Disease. Antibiotics 2021, 10, 327. Norins, L.C. Licensed Anti-Microbial Drugs Logical for Clinical Trials against Pathogens Currently Suspected in Alzheimer’s Disease. Antibiotics 2021, 10, 327.

Journal reference: Antibiotics 2021, 10, 327
DOI: 10.3390/antibiotics10030327

Abstract

There is now considerable evidence that several infectious agents (viruses, bacteria, or parasites) may play a contributing role in the development of Alzheimer’s disease (AD). The six primary suspects are herpes viruses, spirochetal bacteria, Chlamydia pneumoniae, Porphyromonas gingivalis, mycobacteria, and toxoplasma parasites. Also, some of the antimicrobial and antiviral agents that are used to treat them have shown promise for AD interventions. I describe this evidence and assert it is now time to accelerate clinical trials of these existing drugs, already federally approved, to determine if such treatments can delay, halt, or reverse AD.

Keywords

Alzheimer’s disease; dementia, beta-amyloid; germ theory; drug development; clinical trials; herpes; spirochetes; Chlamydia pneumoniae; Porphyromonas gingivalis; toxoplasma; mycobacteria

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