Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Newcastle Disease Virus Induced Pathologies Severely Affect the Exocrine and Endocrine Functions of the Pancreas in Chickens

Zaib Ur Rehman
ORCID logo ,
Shanhui Ren
,
Salman Latif Butt
,
Zahid Manzoor
,
Javid Iqbal
,
Muhammad Naveed Anwar
,
Yingjie Sun
ORCID logo ,
Xusheng Qiu
,
Lei Tan
ORCID logo ,
Ying Liao
,
Cuiping Song
,
Weiwei Liu
,
Chunchun Meng
* ,
Chan Ding
*
Version 1 : Received: 28 January 2021 / Approved: 29 January 2021 / Online: 29 January 2021 (12:38:05 CET)

A peer-reviewed article of this Preprint also exists.

Rehman, Z.U.; Ren, S.; Butt, S.L.; Manzoor, Z.; Iqbal, J.; Anwar, M.N.; Sun, Y.; Qiu, X.; Tan, L.; Liao, Y.; Song, C.; Liu, W.; Meng, C.; Ding, C. Newcastle Disease Virus Induced Pathologies Severely Affect the Exocrine and Endocrine Functions of the Pancreas in Chickens. Genes 2021, 12, 495. Rehman, Z.U.; Ren, S.; Butt, S.L.; Manzoor, Z.; Iqbal, J.; Anwar, M.N.; Sun, Y.; Qiu, X.; Tan, L.; Liao, Y.; Song, C.; Liu, W.; Meng, C.; Ding, C. Newcastle Disease Virus Induced Pathologies Severely Affect the Exocrine and Endocrine Functions of the Pancreas in Chickens. Genes 2021, 12, 495.

Abstract

Newcastle disease virus (NDV) causes a highly contagious and devastating disease in poultry, Newcastle disease (ND). ND causes heavy economic losses to the global poultry industry by decreasing the growth rate, decrease egg productions, mortality, and morbidity. Although, significant advances have been made in the vaccine development, but outbreaks are reported in vaccinated birds leading to overall decreased growth rate. In this study, we report the damage caused by the NDV infection in the pancreatic tissues of vaccinated as well as specific pathogen free chickens. The histopathological examination of the pancreas showed sever damage in the form of partial depletion of zymogen granules, acinar cell vacuolization, necrosis, and apoptosis, congestion in the large and small vessels, sloughing of epithelial cells of pancreatic duct, and mild perivascular edema. Increased plasma levels of corticosterone, somatostatin, were observed in NDV infected chicks at 3 and 5-day post infection (DPI). Slight decrease in the plasma concentrations of the insulin were noticed at 5 DPI. Significant changes were not observed in the plasma levels of glucagon. Furthermore, NDV infection has decreases the activity and mRNA expression of amylase, lipase, and trypsin from the pancreas. Taken together, our findings highlight that NDV induces extensive tissue damage in pancreas, decrease the activity and expression of pancreatic enzymes and increase plasma corticosterone and somatostatin.

Keywords

Newcastle disease virus; chicken; pancreas; hormone; enzymes; histopathology

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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