Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Sources of ROS Species an Its Harmful and Benefical Effects on Human Health

Version 1 : Received: 28 January 2021 / Approved: 29 January 2021 / Online: 29 January 2021 (09:01:24 CET)

How to cite: Munir, S. Sources of ROS Species an Its Harmful and Benefical Effects on Human Health . Preprints 2021, 2021010606 (doi: 10.20944/preprints202101.0606.v1). Munir, S. Sources of ROS Species an Its Harmful and Benefical Effects on Human Health . Preprints 2021, 2021010606 (doi: 10.20944/preprints202101.0606.v1).

Abstract

When the antioxidants in our immune system cannot neutralize or convert Reactive oxygen species into safe molecules at the rate at which it is produced then this imbalance is termed as “oxidative stress”. It is related with a wide array of diseases that includes cancer, diabetes, cardiovascular diseases, hypertension etc. These ROS species however are utmost essential for the proper functioning of human body which are produced as a consequence of partial oxidation of cellular metabolism performing essential functions such as protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. The sources by which these are produced can be broadly classified are intrinsic and extrinsic sources. There are variety of natural antioxidant enzymes of human body that combat against this oxidative stress. The extrinsic sources of ROS include the use of natural plants, extracted flavonoids and vitamins. In this review we will briefly explain how the sources of ROS, its essential function in human body, its elevation and associated damage to organs and effect on various diseases, and a hope of finding a way of how this oxidative stress can be exploited for therapeutic potential.

Subject Areas

ROS; sources of ROS; oxidative stress; ROS and cancer

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