Calcium Channels in Retinal Function and Disease

Brittany Williams; Wesley Maddox; Amy Lee

doi:10.20944/preprints202101.0466.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 21 January 2021 / Approved: 25 January 2021 / Online: 25 January 2021 (10:09:55 CET)

Voltage-gated Ca²⁺ (Ca_v) channels play pivotal roles in regulating gene transcription, neuronal excitability, and neurotransmitter release. In order to meet the spatial and temporal demands of visual signaling, Ca_v channels exhibit unusual properties in the retina compared to their counterparts in other areas of the nervous system. Here, we review current concepts regarding the specific subtypes of Ca_v channels expressed in the retina, their intrinsic properties and forms of modulation, and how their dysregulation could lead to retinal disease.

ribbon synapse; photoreceptor; Ca2+; neurotransmitter release; ion channel

Medicine and Pharmacology, Ophthalmology

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Calcium Channels in Retinal Function and Disease

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