Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Calcium Channels in Retinal Function and Disease

Version 1 : Received: 21 January 2021 / Approved: 25 January 2021 / Online: 25 January 2021 (10:09:55 CET)

How to cite: Williams, B.; Maddox, W.; Lee, A. Calcium Channels in Retinal Function and Disease. Preprints 2021, 2021010466 (doi: 10.20944/preprints202101.0466.v1). Williams, B.; Maddox, W.; Lee, A. Calcium Channels in Retinal Function and Disease. Preprints 2021, 2021010466 (doi: 10.20944/preprints202101.0466.v1).

Abstract

Voltage-gated Ca2+ (Cav) channels play pivotal roles in regulating gene transcription, neuronal excitability, and neurotransmitter release. In order to meet the spatial and temporal demands of visual signaling, Cav channels exhibit unusual properties in the retina compared to their counterparts in other areas of the nervous system. Here, we review current concepts regarding the specific subtypes of Cav channels expressed in the retina, their intrinsic properties and forms of modulation, and how their dysregulation could lead to retinal disease.

Keywords

ribbon synapse; photoreceptor; Ca2+; neurotransmitter release; ion channel

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