Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Female Germ Cell Development, Functioning and Associated Adversities Under Unfavorable Circumstances

Version 1 : Received: 15 January 2021 / Approved: 18 January 2021 / Online: 18 January 2021 (09:14:54 CET)

A peer-reviewed article of this Preprint also exists.

Bharti, D.; Tikka, M.; Lee, S.-Y.; Bok, E.-Y.; Lee, H.-J.; Rho, G.-J. Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances. Int. J. Mol. Sci. 2021, 22, 1979. Bharti, D.; Tikka, M.; Lee, S.-Y.; Bok, E.-Y.; Lee, H.-J.; Rho, G.-J. Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances. Int. J. Mol. Sci. 2021, 22, 1979.

Journal reference: Int. J. Mol. Sci. 2021, 22, 1979
DOI: 10.3390/ijms22041979

Abstract

In the present era, infertility is one of the major issues which restricts many couples to have their own kids. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male or female germ cell development, unhealthy and improper lifestyles, diseases like cancer and associated chemo-or-radiation therapies, congenital disorders etc. may be responsible for infertility. Therefore, it is highly important to understand the basic concepts of germ cell development including primordial germ cell (PGC) formation, specification, migration, entry to genital ridges and their molecular mechanisms, activated pathways, paracrine and autocrine signaling, along with possible alteration which can hamper germ cell development and can cause adversities like cancer progression and infertility. Knowing all these aspects in a proper way can be very much helpful in improving our understanding about gametogenesis and finding possible ways to cure related disorders. Here in this review, various aspects of gametogenesis especially female gametes and relevant factors causing functional impairment have been thoroughly discussed.

Subject Areas

gametogenesis; oocytes; pathways; signaling; stem cells; differentiation; tumor; cancer

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.