Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Histologic Changes in Eccrine Apparatus in Patients With Sjogren Syndrome and No Evidence of Anhidrosis

Version 1 : Received: 11 January 2021 / Approved: 12 January 2021 / Online: 12 January 2021 (13:59:43 CET)

How to cite: Pukhalskaya, T.; Smoller, B.R. Histologic Changes in Eccrine Apparatus in Patients With Sjogren Syndrome and No Evidence of Anhidrosis. Preprints 2021, 2021010221 (doi: 10.20944/preprints202101.0221.v1). Pukhalskaya, T.; Smoller, B.R. Histologic Changes in Eccrine Apparatus in Patients With Sjogren Syndrome and No Evidence of Anhidrosis. Preprints 2021, 2021010221 (doi: 10.20944/preprints202101.0221.v1).

Abstract

Sjogren syndrome (SS) is an autoimmune disease that involves salivary and lacrimal glands. There are rare articles describing hypohidrosis or anhidrosis in SS patients. Little is known about the histologic findings seen in patients with SS who do not report decreased sweating. We analyzed skin samples from 31 patients with SS who had undergone skin biopsies for reasons not related to SS. We assessed the number, distribution and pathologic changes within and around the eccrine ducts, glands and acrosyringia. The composition of the inflammatory infiltrate was additionally accessed utilizing immunohistochemical stains. Overall, in 60% of cases we observed some degree of inflammation. In virtually all cases the inflammatory infiltrate was located around the eccrine ducts at a distance from the non-SS pathology. It was mainly composed of CD3+ T cells with increasing number of B and plasma cells as periductal inflammation intensified. This study is the first histologic analysis of asymptomatic skin in patients with SS. It demonstrates the presence of skin involvement in the majority of SS patients. Our results emphasize the importance of systematic skin evaluation in this category of patients as well as counseling, early preventive measurements and timely treatment when indicated.

Subject Areas

Sjogren syndrome; xerosis; anhidrosis; eccrine apparatus

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