Version 1
: Received: 5 January 2021 / Approved: 6 January 2021 / Online: 6 January 2021 (20:38:36 CET)
Version 2
: Received: 26 January 2021 / Approved: 27 January 2021 / Online: 27 January 2021 (15:08:12 CET)
How to cite:
Vasques Nonaka, C. K.; Miranda Franco, M.; Gräf, T.; Almeida Mendes, A. V.; Santana de Aguiar, R.; Giovanetti, M.; Solano de Freitas Souza, B. Genomic Evidence of a Sars-Cov-2 Reinfection Case With E484K Spike Mutation in Brazil. Preprints2021, 2021010132. https://doi.org/10.20944/preprints202101.0132.v1
Vasques Nonaka, C. K.; Miranda Franco, M.; Gräf, T.; Almeida Mendes, A. V.; Santana de Aguiar, R.; Giovanetti, M.; Solano de Freitas Souza, B. Genomic Evidence of a Sars-Cov-2 Reinfection Case With E484K Spike Mutation in Brazil. Preprints 2021, 2021010132. https://doi.org/10.20944/preprints202101.0132.v1
Vasques Nonaka, C. K.; Miranda Franco, M.; Gräf, T.; Almeida Mendes, A. V.; Santana de Aguiar, R.; Giovanetti, M.; Solano de Freitas Souza, B. Genomic Evidence of a Sars-Cov-2 Reinfection Case With E484K Spike Mutation in Brazil. Preprints2021, 2021010132. https://doi.org/10.20944/preprints202101.0132.v1
APA Style
Vasques Nonaka, C. K., Miranda Franco, M., Gräf, T., Almeida Mendes, A. V., Santana de Aguiar, R., Giovanetti, M., & Solano de Freitas Souza, B. (2021). Genomic Evidence of a Sars-Cov-2 Reinfection Case With E484K Spike Mutation in Brazil. Preprints. https://doi.org/10.20944/preprints202101.0132.v1
Chicago/Turabian Style
Vasques Nonaka, C. K., Marta Giovanetti and Bruno Solano de Freitas Souza. 2021 "Genomic Evidence of a Sars-Cov-2 Reinfection Case With E484K Spike Mutation in Brazil" Preprints. https://doi.org/10.20944/preprints202101.0132.v1
Abstract
To date, uncertainty remains about how long the protective immune responses against SARS-CoV-2 persists and the first reports of suspected reinfection began to be described in recovered patients months after the first episode. Viral evolution may favor reinfections, and the recently described spike mutations, particularly in the receptor binding domain (RBD) in SARS-CoV-2 lineages circulating in the UK, South Africa, and most recently in Brazil, have raised concern on their potential impact in infectivity and immune escape. We report the first case of reinfection from genetically distinct SARS-CoV-2 lineage presenting the E484K spike mutation in Brazil, a variant associated with escape from neutralizing antibodies.
Keywords
SARS-CoV-2; reinfection; E484K
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.