Genomic Evidence of a Sars-Cov-2 Reinfection Case With E484K Spike Mutation in Brazil

Carolina Kymie Vasques Nonaka; Marília Miranda Franco; Tiago Gräf; Ana Verena Almeida Mendes; Renato Santana de Aguiar; Marta Giovanetti; Bruno Solano de Freitas Souza

doi:10.20944/preprints202101.0132.v1

Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 5 January 2021 / Approved: 6 January 2021 / Online: 6 January 2021 (20:38:36 CET)
Version 2 : Received: 26 January 2021 / Approved: 27 January 2021 / Online: 27 January 2021 (15:08:12 CET)

To date, uncertainty remains about how long the protective immune responses against SARS-CoV-2 persists and the first reports of suspected reinfection began to be described in recovered patients months after the first episode. Viral evolution may favor reinfections, and the recently described spike mutations, particularly in the receptor binding domain (RBD) in SARS-CoV-2 lineages circulating in the UK, South Africa, and most recently in Brazil, have raised concern on their potential impact in infectivity and immune escape. We report the first case of reinfection from genetically distinct SARS-CoV-2 lineage presenting the E484K spike mutation in Brazil, a variant associated with escape from neutralizing antibodies.

SARS-CoV-2; reinfection; E484K

LIFE SCIENCES, Biochemistry

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Genomic Evidence of a Sars-Cov-2 Reinfection Case With E484K Spike Mutation in Brazil

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