Working Paper Review Version 1 This version is not peer-reviewed

An Overview on Dialysis on Pregnancy

Version 1 : Received: 29 December 2020 / Approved: 30 December 2020 / Online: 30 December 2020 (16:55:39 CET)

How to cite: Bruno Vecchio, R.C.; Del Negro, V.; Savastano, G.; Porpora, M.G.; Piccioni, M.G. An Overview on Dialysis on Pregnancy. Preprints 2020, 2020120765 Bruno Vecchio, R.C.; Del Negro, V.; Savastano, G.; Porpora, M.G.; Piccioni, M.G. An Overview on Dialysis on Pregnancy. Preprints 2020, 2020120765

Abstract

Background. Pregnancy rates in women on dialysis have increased in the last decades, thus making it a topic of growing interest. The rarity of this event is predominantly due to fertility problems and to the high rates of pregnancy failure including stillbirth, fetal and neonatal deaths [1]. Methods. We conducted a narrative review of existent literature in order to analyse the major issues about pregnancy on dialysis to give the reader a full updated prospective about this topic which, even if not common, is becoming more and more frequent. Results. Even if recently acquired knowledge has improved diagnosis and treatment of dialysis pregnancies focusing on several aspects, pregnancy on dialysis remains a great challenge for obstetricians and should be managed by a multidisciplinary expertise team. Conclusion. Dialysis in pregnancy may be necessary for women previously affected by end stage renal disease (ESRD) becoming pregnant, or in case of acute renal injury presenting for the first time during gestation or, again in case of existent renal pathology worsening during pregnancy and requiring dialysis. Although some evidence suggests that more intensive dialysis regimens are correlated with better obstetric outcomes, the optimal therapeutic protocol still remains to be established.

Subject Areas

Dyalisis in pregnancy; End stage renal disease; haemodyalisis; peritoneal dyalisis; intensive dyalisis regimen; preeclampsia

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