Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Prevalence of Insulin Resistance and the Associated Risk Factors in a Sample of 14–18-Year-Old Slovak Adolescents

Version 1 : Received: 30 December 2020 / Approved: 30 December 2020 / Online: 30 December 2020 (15:16:17 CET)

How to cite: Jurkovicova, J.; Hirosova, K.; Vondrova, D.; Samohyl, M.; Stefanikova, Z.; Filova, A.; Kachutova, I.; Babjakova, J.; Argalasova, L. The Prevalence of Insulin Resistance and the Associated Risk Factors in a Sample of 14–18-Year-Old Slovak Adolescents. Preprints 2020, 2020120759 (doi: 10.20944/preprints202012.0759.v1). Jurkovicova, J.; Hirosova, K.; Vondrova, D.; Samohyl, M.; Stefanikova, Z.; Filova, A.; Kachutova, I.; Babjakova, J.; Argalasova, L. The Prevalence of Insulin Resistance and the Associated Risk Factors in a Sample of 14–18-Year-Old Slovak Adolescents. Preprints 2020, 2020120759 (doi: 10.20944/preprints202012.0759.v1).

Abstract

The prevalence of cardiometabolic risk factors has increased in Slovakian adolescents as a result of serious lifestyle changes. This cross-sectional study aimed to assess the prevalence of insulin resistance (IR) and the associations with cardiometabolic and selected lifestyle risk factors in a sample of Slovak adolescents. In total, 2,629 adolescents (45.8% males) aged between 14 and 18 years were examined in the study. Anthropometric parameters, blood pressure, and resting heart rate were measured, fasting venous blood samples were analysed, and HOMA-IR was calculated. The mean HOMA-IR was 2.45±1.91 without a significant intersexual difference. IR (cut-off point for HOMA-IR=3.16) was detected in 18.6% of adolescents (19.8% males, 17.6% females). IR was strongly associated with overweight/obesity (especially central) and with almost all monitored cardiometabolic factors, except for TC and systolic BP in females. The multivariate model selected variables such as low level of physical fitness, insufficient physical activity, breakfast skipping, a small number of daily meals, frequent consumption of sweetened beverages, and low educational level of fathers as the significant risk factors of IR in adolescents. Recognizing the main lifestyle risk factors and early IR identification is important in terms of the performance of preventive strategies. Weight reduction, regular physical activity, and healthy eating habits can improve insulin sensitivity and decrease the incidence of metabolic syndrome, type 2 diabetes, and CVD in adulthood.

Subject Areas

adolescents; cardiometabolic risk factors; insulin resistance; abdominal obesity; lifestyle; nutritional habits

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