PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome
Version 1
: Received: 30 December 2020 / Approved: 30 December 2020 / Online: 30 December 2020 (14:15:47 CET)
How to cite:
Nakanishi, N.; Tsutsumi, R.; Hara, K.; Matsuo, M.; Sakaue, H.; Oto, J. Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome. Preprints2020, 2020120755 (doi: 10.20944/preprints202012.0755.v1).
Nakanishi, N.; Tsutsumi, R.; Hara, K.; Matsuo, M.; Sakaue, H.; Oto, J. Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome. Preprints 2020, 2020120755 (doi: 10.20944/preprints202012.0755.v1).
Cite as:
Nakanishi, N.; Tsutsumi, R.; Hara, K.; Matsuo, M.; Sakaue, H.; Oto, J. Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome. Preprints2020, 2020120755 (doi: 10.20944/preprints202012.0755.v1).
Nakanishi, N.; Tsutsumi, R.; Hara, K.; Matsuo, M.; Sakaue, H.; Oto, J. Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome. Preprints 2020, 2020120755 (doi: 10.20944/preprints202012.0755.v1).
Abstract
Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interplays the contraction of actin-containing thin filaments and myosin-containing thick filaments. The breakdown product of titin has been measurable in urine as urinary titin N-fragments. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.