Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study

Version 1 : Received: 28 December 2020 / Approved: 28 December 2020 / Online: 28 December 2020 (16:54:31 CET)

A peer-reviewed article of this Preprint also exists.

de la Cruz Conty, M.L.; Encinas Pardilla, M.B.; Garcia Sanchez, M.; Gonzalez Rodriguez, L.; Muner-Hernando, M.L.; Royuela Vicente, A.; Pintado Recarte, P.; Martinez Varea, A.; Martinez Diago, C.; Cruz Melguizo, S.; Martinez-Perez, O.; on behalf of the Spanish Obstetric Emergency Group. Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study. Vaccines 2021, 9, 31. de la Cruz Conty, M.L.; Encinas Pardilla, M.B.; Garcia Sanchez, M.; Gonzalez Rodriguez, L.; Muner-Hernando, M.L.; Royuela Vicente, A.; Pintado Recarte, P.; Martinez Varea, A.; Martinez Diago, C.; Cruz Melguizo, S.; Martinez-Perez, O.; on behalf of the Spanish Obstetric Emergency Group. Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study. Vaccines 2021, 9, 31.

Journal reference: Vaccines 2021, 9, 31
DOI: 10.3390/vaccines9010031

Abstract

The COVID-19 pandemic has raised questions about the possible cross immunity resulting from common vaccination programs and SARS-CoV-2 infection. Therefore, the Spanish Obstetric Emergency group performed a multicenter prospective study on the vaccination status of Influenza and Tdap (diphtheria, tetanus and pertussis vaccine boost administered in adulthood) in consecutive cases of SARS-CoV-2 infection in a pregnancy cohort, in order to assess its possible association with the clinical presentation and severity of symptoms of SARS-CoV-2 infection, as well as to determine the factors that may affect vaccination adherence. 1,150 SARS-CoV-2 positive pregnant women from 78 Spanish hospitals were analyzed: 183 had not received either vaccine, 23 had been vaccinated for Influenza only, 529 for Tdap only and 415 received both vaccines. No association was observed between the vaccination status and the clinical presentation of SARS-CoV-2 infection and/or the severity of symptoms. However, a lower adherence to the administration of both vaccines was observed in the Latin-American subgroup. Based on the results above, we reinforce the importance of maternal vaccination programs in the actual pandemic. Health education campaigns should be specially targeted to groups less likely to participate in these programs, as well as for a future SARS-CoV-2 vaccination campaign.

Subject Areas

SARS-CoV-2; covid 19; pregnancy; passive immunization; maternal immunization; influenza vaccines; diphtheria tetanus pertussis vaccine

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