Version 1
: Received: 24 December 2020 / Approved: 25 December 2020 / Online: 25 December 2020 (13:00:28 CET)
How to cite:
Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Preprints2020, 2020120659 (doi: 10.20944/preprints202012.0659.v1).
Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Preprints 2020, 2020120659 (doi: 10.20944/preprints202012.0659.v1).
Cite as:
Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Preprints2020, 2020120659 (doi: 10.20944/preprints202012.0659.v1).
Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Preprints 2020, 2020120659 (doi: 10.20944/preprints202012.0659.v1).
Abstract
Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains as a novel area of study. This review shows accumulating evidence on the contribution of Pirin in epithelial cancers, signaling pathways involved, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.
Subject Areas
Pirin; cancer; epithelial
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.