Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Corvalan, A.H.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Biology2021, 10, 116.
Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Corvalan, A.H.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Biology 2021, 10, 116.
Abstract
Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains as a novel area of study. This review shows accumulating evidence on the contribution of Pirin in epithelial cancers, signaling pathways involved, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.
Keywords
Pirin; cancer; epithelial
Subject
LIFE SCIENCES, Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
