Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

Francisco Perez-Dominguez; Diego Carrillo-Beltrán; Rancés Blanco; Juan P. Muñoz; Grettell León-Cruz; Ulises Urzúa; Gloria M. Calaf; Francisco Aguayo

doi:10.20944/preprints202012.0659.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 24 December 2020 / Approved: 25 December 2020 / Online: 25 December 2020 (13:00:28 CET)

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains as a novel area of study. This review shows accumulating evidence on the contribution of Pirin in epithelial cancers, signaling pathways involved, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.

Pirin; cancer; epithelial

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Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

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