Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

Francisco Perez-Dominguez; Diego Carrillo-Beltrán; Rancés Blanco; Juan P. Muñoz; Grettell León-Cruz; Ulises Urzúa; Gloria M. Calaf; Francisco Aguayo

doi:10.20944/preprints202012.0659.v1

A peer-reviewed article of this Preprint also exists.

Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Corvalan, A.H.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Biology 2021, 10, 116. Perez-Dominguez, F.; Carrillo-Beltrán, D.; Blanco, R.; Muñoz, J.P.; León-Cruz, G.; Corvalan, A.H.; Urzúa, U.; Calaf, G.M.; Aguayo, F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Biology 2021, 10, 116.

Journal reference: Biology 2021, 10, 116
DOI: 10.3390/biology10020116

Abstract

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains as a novel area of study. This review shows accumulating evidence on the contribution of Pirin in epithelial cancers, signaling pathways involved, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.

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Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

Abstract

Subject Areas

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