Preprint Hypothesis Version 3 Preserved in Portico This version is not peer-reviewed

The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research

Version 1 : Received: 20 December 2020 / Approved: 21 December 2020 / Online: 21 December 2020 (11:12:31 CET)
Version 2 : Received: 25 March 2021 / Approved: 25 March 2021 / Online: 25 March 2021 (15:14:06 CET)
Version 3 : Received: 14 November 2021 / Approved: 15 November 2021 / Online: 15 November 2021 (13:34:33 CET)

How to cite: Marsellach, X. The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research. Preprints 2020, 2020120506. https://doi.org/10.20944/preprints202012.0506.v3 Marsellach, X. The Principle of Continuous Biological Information Flow as the Fundamental Foundation for the Biological Sciences. Implications for Ageing Research. Preprints 2020, 2020120506. https://doi.org/10.20944/preprints202012.0506.v3

Abstract

The current state of biological knowledge contains an unresolved paradox: life as a continuity in the face of the phenomena of ageing. In this manuscript I propose a theoretical framework that offers a solution for this apparent contradiction. The framework proposed is based on a rethinking of what ageing is at a molecular level, as well as on a rethinking of the mechanisms in charge of the flow of information from one generation to the following ones. I propose an information-based conception of ageing instead of the widely accepted damage-based conception of ageing and propose a full recovery of the chromosome theory of inheritance to describe the intergenerational flow of information. Altogether the proposed framework allows a precise and unique definition of what life is: a continuous flow of biological information. The proposed framework also implies that ageing is merely a consequence of the way in which epigenetically-coded phenotypic characteristics are passed from one generation to the next ones.

Keywords

Ageing; Epigenetics

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Comments (1)

Comment 1
Received: 15 November 2021
Commenter: Xavi Marsellach
Commenter's Conflict of Interests: Author
Comment: This manuscript has been updated.
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