Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family

Version 1 : Received: 20 December 2020 / Approved: 21 December 2020 / Online: 21 December 2020 (10:46:22 CET)

How to cite: Styrpejko, D.J.; Cuajungco, M..P. Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family. Preprints 2020, 2020120501 (doi: 10.20944/preprints202012.0501.v1). Styrpejko, D.J.; Cuajungco, M..P. Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family. Preprints 2020, 2020120501 (doi: 10.20944/preprints202012.0501.v1).

Abstract

A growing body of evidence continues to demonstrate the vital roles that zinc and its transporters play on human health. The solute carrier (SLC) 30 and 39 families, with ten and fourteen members, respectively, control zinc transport in cells. TMEM163, a recently characterized zinc transporter, has similar characteristics in both structure and function to the SLC30 family. This review examines recent data that reveal TMEM163 to be a zinc efflux transporter and a new member of the cation diffusion facilitator (CDF) family of mammalian zinc transporter (ZNT) proteins. It also discusses reports that implicate TMEM163 in various human diseases.

Subject Areas

zinc; cation diffusion facilitator; zinc transporter; SV31

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