Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effectiveness of Denosumab Therapy after Treatment with Bisphosphonates in Women Affected by Osteoporosis: A Real-Life Study

Chiara Marocco
,
Giovanna Zimatore
* ORCID logo ,
Edoardo Mocini
,
Rachele Fornari
,
Giovanni Iolascon
,
Maria Chiara Gallotta
ORCID logo ,
Viviana Maria Bimonte
,
Carlo Baldari
ORCID logo ,
Andrea Lenzi
,
Silvia Migliaccio
*
Version 1 : Received: 20 December 2020 / Approved: 21 December 2020 / Online: 21 December 2020 (10:42:15 CET)

A peer-reviewed article of this Preprint also exists.

Marocco, C.; Zimatore, G.; Mocini, E.; Fornari, R.; Iolascon, G.; Gallotta, M.C.; Bimonte, V.M.; Baldari, C.; Lenzi, A.; Migliaccio, S. Efficacy of Denosumab Therapy Following Treatment with Bisphosphonates in Women with Osteoporosis: A Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 1728. Marocco, C.; Zimatore, G.; Mocini, E.; Fornari, R.; Iolascon, G.; Gallotta, M.C.; Bimonte, V.M.; Baldari, C.; Lenzi, A.; Migliaccio, S. Efficacy of Denosumab Therapy Following Treatment with Bisphosphonates in Women with Osteoporosis: A Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 1728.

Abstract

Denosumab is a human monoclonal antibody that neutralizes RANKL, a cytokine able to interact with the RANK receptor on preosteoclasts and osteoclasts, decreasing their recruitment and differentiation, leading to a decreased bone resorption. The aim of this observational real-life study was to analyze adherence to denosumab therapy, its effectiveness in increasing bone mineral density (BMD) and in modulating biochemical skeletal markers upon previous treatments with bisphosphonates in a group of post-menopausal women affected by osteoporosis. Women were recruited in the specialized center from March 2012 to September 2019. Biochemical markers were recorded at baseline and every six months prior to subsequent drug injection. Dual X-ray Absorptiometry was requested at baseline and after 18/24 months. Comparing BMD at baseline and after denosumab therapy in naive patients and in those previously treated with bisphosphonates, a positive therapeutic effect was observed in both groups. The results of our real-life study demonstrate, as expected, that BMD values significantly increased upon denosumab treatment. Interestingly, denosumab showed an increased effectiveness in patients previously treated with bisphosphonates. Moreover, biochemical markers data indicate that osteoporotic patients, without other concomitant unstable health conditions, could be evaluated once a year, decreasing the number of specialistic center access.

Keywords

Osteoporosis; anti-resorptive drugs; therapeutic adherence; bone mineral density; biochemical markers

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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