Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Long-Haul COVID-19: Putative Pathophysiology, Risk Factors, and Treatments

Shin Jie Yong
*
Version 1 : Received: 9 December 2020 / Approved: 10 December 2020 / Online: 10 December 2020 (09:42:20 CET)

A peer-reviewed article of this Preprint also exists.

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DOI: 10.1080/23744235.2021.1924397

Abstract

Long-haul COVID-19 illness first gained widespread recognition among social support groups and later in scientific and medical communities. This illness is mysterious as it affects COVID-19 survivors at all levels of disease severity, even younger adults and children. While the precise definition may be lacking, the defining symptoms are fatigue, dyspnea, and headache that last for months after hospital discharge. The less typical symptoms may include cognitive impairments, chest and joint pains, myalgia, smell and taste dysfunctions, cough, mood changes, and gastrointestinal and cardiac issues. Presently, there is limited literature discussing the possible pathophysiology, risk factors, and treatments in long-haul COVID-19, which the current review aims to address. In brief, long-haul COVID-19 may be driven by long-term lung and brain damage and unresolved inflammation from multiple sources. The associated risk factors may include female sex, more than five early symptoms, early dyspnea, and specific biomarkers like D-dimer. While only rehabilitation training has been useful for long-haul COVID-19, therapeutics repurposed from mast cell activation syndrome, myalgic encephalomyelitis/chronic fatigue syndrome, and pulmonary fibrosis also hold potential. In sum, this review hopes to provide the current understanding of what is known about long-haul COVID-19.

Keywords

COVID-19; SARS-CoV-2; long-haul; inflammation; tissue damage; drug repurposing

Subject

MEDICINE & PHARMACOLOGY, Allergology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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