Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Methods Used and Application of the Mouse Grimace Scale in Biomedical Research 10 Years on: A Systematic Scoping Review

Version 1 : Received: 7 December 2020 / Approved: 7 December 2020 / Online: 7 December 2020 (15:13:05 CET)

A peer-reviewed article of this Preprint also exists.

Whittaker, A.L.; Liu, Y.; Barker, T.H. Methods Used and Application of the Mouse Grimace Scale in Biomedical Research 10 Years On: A Scoping Review. Animals 2021, 11, 673. Whittaker, A.L.; Liu, Y.; Barker, T.H. Methods Used and Application of the Mouse Grimace Scale in Biomedical Research 10 Years On: A Scoping Review. Animals 2021, 11, 673.

Journal reference: Animals 2021, 11, 673
DOI: 10.3390/ani11030673

Abstract

The Mouse Grimace Scale (MGS) was developed 10 years ago to assess pain through characterisation of changes in five facial features or action units. The strength of the technique is that it is proposed to be a measure of spontaneous or non-evoked pain. A comprehensive scoping review of the academic literature was performed. The MGS has been employed mainly in evaluation of acute pain, particularly in the pain and neuroscience research fields. There has however been use of the technique in a wide range of fields, and based on limited study it does appear to have utility for pain assessment across a spectrum of animal models. Use of the method does allow detection of pain of a longer duration, up to a month post-initial insult. There has been less use of the technique using real-time methods and this is an area in need of further research.

Subject Areas

Mouse Grimace Scale; Pain; Validity; Methods; Reliability

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