Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance During General Anesthesia - A New Era in Patient Safety Standards and Healthcare Management

Version 1 : Received: 24 November 2020 / Approved: 26 November 2020 / Online: 26 November 2020 (08:35:42 CET)
Version 2 : Received: 23 January 2021 / Approved: 25 January 2021 / Online: 25 January 2021 (17:02:57 CET)

A peer-reviewed article of this Preprint also exists.

Rogobete, A.F.; Bedreag, O.H.; Papurica, M.; Popovici, S.E.; Bratu, L.M.; Rata, A.; Barsac, C.R.; Maghiar, A.; Garofil, D.N.; Negrea, M.; Petcu, L.B.; Toma, D.; Dumbuleu, C.M.; Rimawi, S.; Sandesc, D. Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance during General Anesthesia—A New Era in Patient Safety Standards and Healthcare Management. Medicina 2021, 57, 132. https://doi.org/10.3390/medicina57020132 Rogobete, A.F.; Bedreag, O.H.; Papurica, M.; Popovici, S.E.; Bratu, L.M.; Rata, A.; Barsac, C.R.; Maghiar, A.; Garofil, D.N.; Negrea, M.; Petcu, L.B.; Toma, D.; Dumbuleu, C.M.; Rimawi, S.; Sandesc, D. Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance during General Anesthesia—A New Era in Patient Safety Standards and Healthcare Management. Medicina 2021, 57, 132. https://doi.org/10.3390/medicina57020132

Journal reference: Medicina 2021
DOI: 10.3390/medicina57020132

Abstract

Worldwide, an increasing number of patients undergo complex surgeries. With the development of general anesthesia techniques and anesthetic substances, the most complex surgical techniques could be developed. In order to adapt the anesthesia according to the particularities of each patient, it is recommended the multimodal monitoring of these patients. Classically, general anesthesia monitoring consists of the analysis of vital functions and gas exchange. Multimodal monitoring refers to the concomitant monitoring of the degree of hypnosis and the nociceptive-antinociceptive balance. By titrating anesthetic drugs according to these parameters, clinical benefits can be obtained, such as hemodynamic stabilization, reduction of awakening times, reduction of post-operative complications. Also, there is an important impact on the status of inflammation and the redox balance. The purpose of this literature review is to present the most modern multimodal monitoring techniques, respectively to discuss the particularities of each technique.

Keywords

depth of anaeshtesia; multimodal monitoring; entropy; bispectral index; surgical plethismographic index; neurotransmission; general anaesthesia; patient safety.

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