Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Preparing for the Storm: Mitigating the Effect of SARS-CoV-2 Induced Hypercytokinemia

Adekunle Rowaiye
* ,
Okiemute Okpalefe
,
Olukemi Onuh
,
Joyce Ogidigo
,
Oluwakemi Oladipo
,
Amoge Ogu
,
Angus Oli
* ,
Samson Olofinase
,
Onyekachi Onyekwere
Version 1 : Received: 20 November 2020 / Approved: 24 November 2020 / Online: 24 November 2020 (09:12:42 CET)

A peer-reviewed article of this Preprint also exists.

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DOI: 10.2147/JIR.S301784

Abstract

With increasing fatalities, the COVID-19 pandemic constitutes a formidable global health challenge. The causative agent, SARS-CoV-2 constantly tests the efficacy of the immune system of its victims. The protective ability of the innate immune system as the first responder largely determines the progression of disease and its clinical prognosis. Evidence suggests that mortalities associated with COVID-19 are largely due to hyperinflammation and a dysregulated immune response. Consequently, the degree of the release of pro-inflammatory cytokines such as IL1, IL-6, and TNF alpha remarkably distinguishes between mild and severe cases of COVID-19. The early prediction of a cytokine storm is made possible by several serum chemistry and hematological markers. The prompt use of these markers for laboratory tests, and the aggressive prevention and management of a cytokine release syndrome is critical in determining the level of morbidity and fatality associated with COVID-19. With respect to the SARS-CoV-2 and the host cell, this literature review focuses on the dynamics of the COVID-19 disease highlighting on the pathogenesis, and the markers of Cytokine Storm. It also proffers solutions by critically looking at the current and potential pharmacological agents that are or can be used to mitigate and manage cytokine storms.

Keywords

COVID-19; SARS-CoV-2; Cytokine Storm; Hyperinflammation; hypercytokinemia

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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