Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Rituximab use in Warm and Cold Autoimmune Hemolytic Anemia

Version 1 : Received: 19 November 2020 / Approved: 23 November 2020 / Online: 23 November 2020 (09:46:33 CET)

A peer-reviewed article of this Preprint also exists.

Murakhovskaya, I. Rituximab Use in Warm and Cold Autoimmune Hemolytic Anemia. J. Clin. Med. 2020, 9, 4034. Murakhovskaya, I. Rituximab Use in Warm and Cold Autoimmune Hemolytic Anemia. J. Clin. Med. 2020, 9, 4034.


Autoimmune hemolytic anemia is a rare condition characterized by destruction of red blood cells with and without involvement of complement. It is associated with significant morbidity and mortality. In warm autoimmune hemolytic anemia less than 50% of patients remain in a long-term remission following initial steroid therapy and subsequent therapies are required. Cold agglutinin disease is a clonal hematologic disorder which requires therapy in majority of patients and responds poorly to steroids and alkylators. Rituximab has a favorable toxicity profile and has demonstrated efficacy in autoimmune hemolytic anemia in first line as well as relapsed setting. Rituximab is the preferred therapy for steroid refractory wAIHA and as part of the first- and second-line treatment of cold agglutinin disease. This article reviews the mechanism of action of the rituximab and current literature its role in management of primary and secondary warm autoimmune hemolytic anemia and cold agglutinin disease.


Autoimmune Hemolytic Anemia Treatment, Warm Autoimmune Hemolytic Anemia, Rituximab, Cold Agglutinin Disease


Medicine and Pharmacology, Immunology and Allergy

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