Preprint Article Version 1 This version is not peer-reviewed

Assessment of Selected Clock Proteins (CLOCK, CRY1) and their Relationship with Biochemical, Anthropometric and Lifestyle Parameters in Hypertensive Patients

Version 1 : Received: 19 November 2020 / Approved: 20 November 2020 / Online: 20 November 2020 (10:16:36 CET)

How to cite: Mikulska, A.A.; Grzelak, T.; Pelczyńska, M.; Bogdański, P.; Czyżewska, K. Assessment of Selected Clock Proteins (CLOCK, CRY1) and their Relationship with Biochemical, Anthropometric and Lifestyle Parameters in Hypertensive Patients. Preprints 2020, 2020110533 (doi: 10.20944/preprints202011.0533.v1). Mikulska, A.A.; Grzelak, T.; Pelczyńska, M.; Bogdański, P.; Czyżewska, K. Assessment of Selected Clock Proteins (CLOCK, CRY1) and their Relationship with Biochemical, Anthropometric and Lifestyle Parameters in Hypertensive Patients. Preprints 2020, 2020110533 (doi: 10.20944/preprints202011.0533.v1).

Abstract

Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins- cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) and to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, quality of sleep) in hypertensive patients. In 25 female with hypertension (HT) and 49 non-hypertensive women (NHT), the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile and glycemia were conducted. Blood pressure and anthropometric measurements, nutritional, exercise and sleep analyses were performed. In HT the CRY1 level was 40.2% lower than in the NHT. No differences were noted in CLOCK concentration between groups. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity and sleep quality, although CRY1 was associated with some anthropometric parameters. There was a negative correlation between the CLOCK concentration and the amount of saturated fatty acids consumed (24h) in HT. That indicates the possible influence of the diet on the CLOCK level. In a detailed prognosis of the risk of hypertension, it is worth considering the measurement of the level of CRY1 in populations with abnormal anthropometric indices.

Subject Areas

circadian clock; cryptochrome 1; circadian locomotor output cycles kaput; hypertension; total antioxidant status; diet; chrononutrition

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