Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Proanthocyanidins and Flavan-3-ols in the Prevention and Treatment of Periodontitis - Antibacterial Effects.

Version 1 : Received: 18 November 2020 / Approved: 19 November 2020 / Online: 19 November 2020 (10:26:44 CET)

How to cite: Nawrot-Hadzik, I.; Matkowski, A.; Hadzik, J.; Dobrowolska-Czopor, B.; Olchowy, C.; Dominiak, M.; Kubasiewicz-Ross, P. Proanthocyanidins and Flavan-3-ols in the Prevention and Treatment of Periodontitis - Antibacterial Effects.. Preprints 2020, 2020110499 (doi: 10.20944/preprints202011.0499.v1). Nawrot-Hadzik, I.; Matkowski, A.; Hadzik, J.; Dobrowolska-Czopor, B.; Olchowy, C.; Dominiak, M.; Kubasiewicz-Ross, P. Proanthocyanidins and Flavan-3-ols in the Prevention and Treatment of Periodontitis - Antibacterial Effects.. Preprints 2020, 2020110499 (doi: 10.20944/preprints202011.0499.v1).

Abstract

Flavan-3-ols and their oligomeric forms called proanthocyanidins are polyphenolic compounds occurring in several foodstuffs and in many medicinal herbs. Their consumption is associated with numerous health benefits. Their bioactivities include antioxidant, anti-inflammatory, cytoprotective, as well as antimicrobial. The latter property is important in prevention and treatment of periodontal diseases. Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process affecting the periodontium. Using non-toxic and efficient natural products such as flavanol derivatives can significantly contribute to alleviating of periodontitis symptoms and prevent the disease progress. In this paper, we systematically review the state-of-the art in antibacterial effects of these compounds from the viewpoint of gum health. There is a significant evidence supporting an importance of antibacterial action exerted by proanthocyanidins from edible fruits, tea and medicinal herbs in inhibition of periodontitis-causing pathogens.

Subject Areas

condensed tannins; proanthocyanidins; flavan-3-ols; periodontitis; gingivitis; gum disease; cranberry; Camellia sinensis; polyphenols

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