Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

3D-Printed Veterinary Dosage Forms – A Comparative Study of Three Semi-Solid Extrusion Printers

Erica Sjöholm
* ,
Rathna Mathiyalagan
ORCID logo ,
Dhayakumar Rajan Prakash
,
Lisa Lindfors
,
Qingbo Wang
,
Xiaoju Wang
,
Samuli Ojala
,
Niklas Sandler
Version 1 : Received: 31 October 2020 / Approved: 2 November 2020 / Online: 2 November 2020 (14:59:30 CET)

A peer-reviewed article of this Preprint also exists.

Sjöholm, E.; Mathiyalagan, R.; Rajan Prakash, D.; Lindfors, L.; Wang, Q.; Wang, X.; Ojala, S.; Sandler, N. 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers. Pharmaceutics 2020, 12, 1239. Sjöholm, E.; Mathiyalagan, R.; Rajan Prakash, D.; Lindfors, L.; Wang, Q.; Wang, X.; Ojala, S.; Sandler, N. 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers. Pharmaceutics 2020, 12, 1239.

Abstract

Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for smaller doses of veterinary medicines. This study aims to investigate the use of three semi-solid extrusion 3D printers in a pharmacy or animal clinic setting for extemporaneous manufacturing of prednisolone containing orodispersible films for veterinary use. Orodispersible films with adequate content uniformity and acceptance values defined by the European Pharmacopoeia was produced with one of the studied printers, namely, the Allevi 2 bioprinter. Smooth and flexible films, with high mechanical strength, neutral pH, and low moisture content were produced with high correlation between prepared design and obtained drug amount, indicating that the Allevi 2 printer could successfully be used to extemporaneously manufacture personalized doses for animals at the point-of-care.

Keywords

3D printing; semi-solid extrusion 3D printing; additive manufacturing; extemporaneous manufacturing; drug delivery; personalized dosage forms; veterinary medicine; prednisolone

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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